Hypertension in Pregnancy
Conditions
Keywords
Hypertension, pregnancy induced, Angiogenic factors
Brief summary
Retrospective cohort study that evaluated 190 subjects admitted with diagnosis of hypertensive disorder of pregnancy, between 24 and 36 6/7 weeks, with an sFlt-1/PlGF index greater than or equal to 110. Data were collected on their clinical course prior to termination of pregnancy, using the last reported sFlt-1/PlGF ratio value to classify the population into four cohorts: values between 110-205, between 206 and 654, between 655 and 999 and greater than 1000.
Interventions
DIAGNOSTIC_TESTStandard of care
No intervention. Clinical evolution was recorded, looking for perinatal complications.
Sponsors
Saint Thomas Hospital, Panama
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
* Diagnosis of hypertensive disorder of pregnancy * Gestational age between 24 - 36 6/7 * sFlt-1/PlGF \> 110
Exclusion criteria
* Gestational age below 23 6/7 weeks and above 37 weeks at the moment of admission. * Absence of sFLt-1/PlGF ratio result.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Kidney injury | From the moment of admission up until discharge after delivery, average 5 to 10 days | Creatinine level \> 1.1 Doubling of creatinine levels when others causes had been excluded |
| Hepatic enzyme abnormalities | From the moment of admission up until discharge after delivery, average 5 to 10 days | Increase of liver enzyme to \> twice the upper limit of normal |
| HELLP Syndrome | From the moment of admission up until discharge after delivery, average 5 to 10 days | Elevated liver enzymes Thrombocytopenia Hemolysis |
| Growth restricted fetus | From the moment of admission up until delivery, average 5 to 10 days | Fetal weight below 10th percentile and abnormal doppler Fetal weight below 3th percentile |
| Stillbirth | From the moment of admission up until discharge after delivery, average 5 to 10 days | Intrauterine fetal demise |
Countries
Panama
Outcome results
None listed