Arteriovenous Plasma Multiomics in Patients With Disorders of Consciousness

Arteriovenous Plasma Multiomics and Inflammatory Factors in Patients With Disorders of Consciousness

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06403176

Enrollment

100

Registered

2024-05-07

Start date

2022-05-01

Completion date

2024-04-30

Last updated

2024-05-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Disorders of Consciousness, Transient Ischemic Attack

Keywords

Plasma metabolism

Brief summary

In order to determine the abnormal cerebral metabolism in the pathological state, we compared the blood of internal jugular vein, superior vena cava and radial artery during central venous catheterization. Metabonomics, proteomics and inflammatory factor microarray were used to detect the material differences in arteriovenous blood of patients with disorders of consciousness. At the same time, we concurrently compared it with the peripheral plasma metabolome of two additional patient cohorts: those in-stent restenosis and non-restenosis.

Detailed description

Background:It is unclear what substances the brain needs to ingest for its activity under pathological conditions Method:The uptake and release of substances by the brain were observed by comparing arterial blood with internal jugular vein blood;The characteristics of brain metabolites were observed by comparing internal jugular vein blood with superior vena cava blood. Compared it with the peripheral plasma metabolome of two additional patient cohorts: those in-stent restenosis and non-restenosis. Objective:By analyzing different substances, this paper briefly describes the pathological mechanism of patients with disorders of consciousness, and looks for potential prognostic biomarkers.

Interventions

OTHERNo intervention

No intervention

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

1.Patients with consciousness disorder caused by various severe brain injuries

Exclusion criteria

1. Patients who have been judged brain dead 2. There are persistent epileptic activity, inhibition or seizure inhibition patterns 3. Recent fever, abnormal liver and kidney function 4. Previous history of neurological or mental illness 5. Have a history of tumor 6. Inflammatory bowel diseases, hyperlipidemia, gastritis

Design outcomes

Primary

Measure	Time frame	Description
Patient clinical outcome	12 months	The patients were followed up for 12 months after blood collection to observe the clinical outcome

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026