Celiac Disease
Conditions
Keywords
celiac disease, inflammation, interferon-gamma, interleukin-15
Brief summary
This study examined the impact of a gluten-free diet on nutritional status and inflammation markers in adult celiac patients compared to a control group. Twenty-six celiac patients and 26 healthy individuals participated. Interviews, dietary records, anthropometric measurements, and blood samples were collected. After six weeks, celiac patients showed improved adherence to the gluten-free diet and increased quality of life scores. While initial micronutrient intake was lower in celiac patients, it improved over the study period. However, there were no significant changes in inflammation markers.
Detailed description
This study aimed to examine the effects of a gluten-free diet on the nutritional status, anthropometric measurements, and serum levels of interferon-gamma (IFN-γ) and interleukin-15 (IL-15) in adult celiac patients, comparing them with a control group. A total of 26 celiac patients aged 18-64 years and 26 healthy individuals as the control group were included. Face-to-face interviews were conducted to determine participants' general characteristics, dietary habits, and physical activity status. Additionally, a retrospective 24-hour dietary recall and food frequency questionnaire were administered to assess dietary intake. Anthropometric measurements and blood samples were collected during the interviews. Celiac patients received education about the gluten-free diet, and follow-up assessments were conducted six weeks later. At the beginning, 53.8% of celiac patients reported always/mostly adhering to the gluten-free diet, which increased to 100.0% after six weeks. The total quality of life scores significantly increased in celiac patients after six weeks. Initial serum IL-15 levels were similar between celiac and control groups, whereas serum IFN-γ levels were significantly higher in celiac patients compared to the control group.
Interventions
BEHAVIORALAdherence to Gluten Free Diet
Participants with a diagnosed celiac disease were following a gluten-free diet. Study observed the adherence to the gluten-free diet for 6 weeks.
Sponsors
Hacettepe University
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
19 Years to 64 Years
Healthy volunteers
Yes
Inclusion criteria
* Adults aged between 19 and 64 years old. * Diagnosis of celiac disease. * Willingness to participate in the study. * Ability to adhere to the study protocol, including dietary restrictions and follow-up assessments. * For the control group, individuals without celiac disease or any other significant health conditions.
Exclusion criteria
* Individuals following diets other than a gluten-free diet. * Individuals adhering to a gluten-free diet for reasons other than celiac disease. * Individuals with gastrointestinal diseases other than celiac disease. * Individuals who have undergone gastrointestinal surgery. * Individuals with mental illnesses. * Cancer patients. * Individuals positive for hepatitis B surface antigen or anti-hepatitis C virus antibody. * Individuals using interferon and/or insulin. * Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum interferon-gamma level | 6 weeks | Serum interferon-gamma level was measured. |
| Serum interleukin-15 levels | 6 weeks | Serum interleukin-15 level was measured. |
| Body weight | 6 weeks | Body weight was measured using body composition analyzer device. |
| Lean body mass | 6 weeks | Lean body mass was measured using body composition analyzer device. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Total energy intake | 6 weeks | Total energy intake was measured using food records. |
Countries
Turkey (Türkiye)
Outcome results
None listed