Pulp Exposure, Dental, Dental Pulp Capping
Conditions
Brief summary
Direct pulp capping technique is one of the oldest known treatments for exposed pulp tissue, and there is a continuous requirement for the most efficient materials to be used in this approach. Successful pulp capping is the usual way to preserve the vitality of tooth and avoid root canal treatment or surgical tooth extraction.
Interventions
OTHERHesperidin
Hesperidin is a natural flavonoid with well-known of its anti-inflammatory properties in many disease. Hesperidin in previous studies has been documented to reduce inflammation as well as pain through suppression of cytokine production, NF-κB activity, and oxidative stress. Hesperidin, as a natural product, have been considered as a promising pulp capping material in several invitro and animal studies. However, the regenerative effect of hesperidin as pulp capping material in human teeth has not yet been reported.
Mineral trioxide aggregate is a cementitious material having various advantages as it is biocompatible, bioactive, osteo-inductive, non-resorbable material with exciting clinical applications, stimulating reparative continuous dentin formation along with maintaining the integrity of the pulp. Moreover, mineral trioxide aggregate provides seal to tooth structure and is of high strength. It is considered the gold standard material for direct pulp capping.
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Good oral hygiene, * Sound wisdom teeth with closed apices with normal pulp vitality response * No periodontal disease or periapical lesions on periapical radiograph * Cooperative patients approving to participate in the study
Exclusion criteria
* Medically compromised participants * Evidence of parafunctional habits * Heavy smokers * Teeth with signs and symptoms of irreversible pulpitis or pulp necrosis * Severe periodontal problems or pathological periapical changes * Teeth with open apex or pulp calcification
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Success Rate (Clinical evaluation) | after 12 weeks | Teeth with vital pulp (numerical values with electric pulp tester) and absence of clinical signs/symptoms (Visual Analog Score for pain) as one reported value indicating clinical success rate (%) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Histomorphometric analysis (Histologic evaluation) | after 12 weeks | Thickness of formed dentin bridge (μm) |
Countries
Egypt
Outcome results
None listed