Patients With Brain Masses/Lesions
Conditions
Brief summary
The aim of this observational register study is to establish a registry that completely records and compiles the data from routinely performed technical examinations (navigated transcranial magnetic stimulation, intraoperative neuromonitoring and stimulation, MRI imaging including tractography and connectome) and clinical tests over time (pre-, intra- and postoperative, under adjuvant therapy, as part of follow-up care) of patients with intracranial masses and lesions.
Interventions
None listed
Sponsors
University Hospital Heidelberg
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Intracranial lesion * Age ≥ 18 years * Written consent to participate in the study
Exclusion criteria
* Age \< 18 years * Patients not able to give consent * Patients with intracranial ferromagnetic metal implants * Patients with implanted electronic devices
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive status | until last patient FU up to 48 months | Higher cognitive functions - determined by the Montreal Cognitive Assessment (MocA) |
| Language status | until last patient FU up to 48 months | Language function tested by the Aphasia Check List |
| Motor status | until last patient FU up to 48 months | Motor function according to the BMRC scale |
| cortical data | until last patient FU up to 48 months | cortical nTMS-Data - distribution according the cortical parellation system |
| Fiber tracts | until last patient FU up to 48 months | Volume of fiber tracts |
| structural imaging (Connectome) | until last patient FU up to 48 months | characteristics of Connectome and Disconnectome analysis (Global Efficiency value) |
Countries
Germany
Outcome results
None listed