Continuous Glucose Monitoring
Conditions
Keywords
blood glucose, insulin
Brief summary
Compared to traditional blood glucose monitoring (TGM), CGM can accurately capture asymptomatic hyperglycemia and hypoglycemia events that are missed by TGM, accounting for 33% and 90% of cases, respectively. Real-time CGM provides instantaneous glucose levels and can also generate alarms for hypoglycemia and hyperglycemia based on preset glucose ranges, assisting patients in making timely adjustments to their glucose levels. Clinical studies have found that glucose control guided by real-time CGM is better, and the decrease in glycosylated hemoglobin levels is positively correlated with the frequency of CGM use. More importantly, although glucose variability can be calculated using conventional blood glucose measurements taken every four to six hours, to further assess precise changes in glucose levels, more detailed and accurate continuous data are required. In this respect, CGM has unparalleled advantages over traditional blood glucose monitoring.While the use of CGM in critically ill patients is still controversial.
Detailed description
We conducted this clinical study to compare the effectiveness of CGM and traditional blood glucose monitoring in guiding blood glucose control in critically ill patients, and to clarify the feasibility of using CGM for critically ill patients. We also aimed to explore the possible factors that affect CGM in critically ill patients.
Interventions
None listed
Sponsors
Study design
Eligibility
Inclusion criteria
* Age≥ 18 years and \< 80 years * ICU stay ≤48 hours * Expected ICU stay \> 24 hours * APACHE II score≥ 8
Exclusion criteria
* local infection within the sensor placement area * Laparotomy within lower abdomen * Participated in this study before * In other clinical trails.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mortality rate during ICU stay | Days from ICU entrance to ICU discharge | Mortality |
| ICU stay | During the ICU stay | Days |
| 28-day mortality rate | 28 days after ICU entrance | Mortality |
| 60-day mortality rate | 60 days after ICU entrance | Mortality |
| CGM measurement | Days within the 1st week after ICU entrance | Test |
| Whole blood or fingertip blood glucose measurement | Days within the 1st week after ICU entrance | Test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Insulin levels | Days within the 1st week after ICU entrance | Test |
| Thyroid hormones and other relevant hormone levels were measured | The 1st day and the 7th day after ICU entrance | Test |
| Serum C-peptide | Days within the 1st week after ICU entrance | Test |
Countries
China