Melanoma (Skin)
Conditions
Brief summary
The goal of this study is to observe metabolic features associated with human melanoma tumors.
Detailed description
This is a single center, correlative study designed to assess metabolic features of melanoma tumors in patients. The study will involve the collection of melanoma tissue at the time of surgical biopsy or excision. All samples will be assessed by mass spectrometry for metabolomic analysis. A subset of patients will have received \[U-13C\]glucose infusions which will be utilized for isotope tracing metabolic analysis. Relevant clinical data (eg survival, metastasis) will be correlated with metabolic findings.
Interventions
None listed
Sponsors
University of Texas Southwestern Medical Center
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with known or probable malignant melanoma lesions requiring surgical biopsy or excision. * Subjects of all races and ethnic origins over age 18.
Exclusion criteria
* Not a surgical candidate * Poorly controlled diabetes
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Glucose Utilisation in the TCA cycle | 5 years | In patients receiving a \[U-13C\]Glucose infusion, assess glucose utilization in the TCA cycle by melanoma tumors (defined as fractional enrichment of 13C-label in TCA metabolites) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Relapse free survival | 5 years | Defined as the time from surgery to disease recurrence or melanoma-related death, whichever occurs first |
| Overall Survival | 5 years | Measured as the time of surgery until death from any cause |
| Development of Lymph Node or Distant Metastasis | 5 years | Defined as yes/no for each type of metastasis |
Countries
United States
Contacts
CONTACTAleuna Lee
PRINCIPAL_INVESTIGATORJennifer Gill, MD, PhD
University of Texas Southwestern Medical Center
Outcome results
None listed