Fertility Preservation for Transfeminine Adolescents Via Semen Cryopreservation or Testicular Sperm Extraction

Succesfull Fertility Preservation for Transfeminine Adolescents Via Semen Cryopreservation or Testicular Sperm Extraction

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06400199

Acronym

TESE

Enrollment

Registered

2024-05-06

Start date

2022-07-01

Completion date

2024-07-01

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gender Dysphoria, Adolescent

Keywords

Testicular sperm extraction, Fertility preservation, Puberty suppresion

Brief summary

The goal of this observational cohort study is to identify and predict parameters for successful testicular sperm extraction (TESE) procedures or semen cryopreservation more accurately and to evaluate the decision making process and the experience of postponing or temporarily discontinuing puberty suppression to undergo successful fertility preservation. in transfeminine (assigned male at birth) adolescents. The main question\[s\] it aims to answer are: * What is the optimal timing for fertility preservation before the start or after temporarily discontinuing puberty suppression puberty suppression * How do transfeminine adolescents and their parents experience the decision making process of fertility preservation * how do transfeminine adolescents and their parents experienced postponing or temporarily discontinuing puberty suppression to undergo successful fertility preservation? Participants will be asked to use their medical data, answer a questionnaire or participate in a (online) interview.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

MALE

Age

10 Years to 18 Years

Healthy volunteers

Yes

Inclusion criteria

* Before start of puberty suppresion with a wish for fertility preservation * After discontinuing puberty suppersion before the start of hormone therapy

Exclusion criteria

* Tanner stage \> 4/5

Design outcomes

Primary

Measure	Time frame	Description
What parameter is best in predicting successful fertility preservation (i.e. spermatazoa are present)	Most recent before the TESE of semen cryopreservation no longer than 3 months old	Testicular volume

Secondary

Measure	Time frame	Description
How do adolescents and parents experience fertility preservation	After refferal to fertility preservation specialist, after every 3 months after the start of Tanner 2, 1 month after the fertility preservation.	self-constructed questionnaires and semi-structed interviews

Countries

Netherlands

Contacts

Primary ContactTessa Stolk, MD

t.h.stolk@amsterdamumc.nl+31623844827

Backup ContactNorah van Mello, MD, PHD

n.vanmello@amsteramumc.nl

Outcome results