Peritoneal Dialysis
Conditions
Brief summary
The study will enroll patients receiving daily peritoneal dialysis who have significant residual native kidney function. The investiators will visit the patients at a routinely scheduled clinic visit and again at a non-routine visit after the patients skip a single day of dialysis. Blood samples will be obtained and a quality of life questionnaire will be administered at both visits. The primary aim will be to determine whether the patients would prefer daily treatment or being allowed to skip one day per week. Other aims will be to determine the effect of skipping a day on plasma levels of urea nitrogen and creatinine.
Detailed description
The patients' preference will be assessed by asking the simple question would you prefer to perform peritoneal dialysis daily of six days per week. The quality of life questionnaire to be used will be the Dialysis Symptom Index (DSI) which has a range of 0 to 150 with a high score reflecting worse quality of life. The chemical to be measured will be the plasma urea nitrogen in mg/dl and the plasma creatinine in mg/dl as measured by the clinical laboratory.
Interventions
OTHERSkip one day of peritoneal dialysis treatment
Skip one day of peritoneal dialysis treatment
Sponsors
Stanford University
Study design
Allocation
NA
Intervention model
SEQUENTIAL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Daily treament with peritoneal dialysis and residual native kidney funciton with residual urea clearance greater than 2 ml/min.
Exclusion criteria
* less than 3 months on peritoneal dialysis * recent change in the dialysis prescriptoin * recent peritonitis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Patient's preference for treatment regimen | Two weeks per patient | Patient's stated preference for dialysis daily versus six days per week |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Symptoms | Two weeks per patient | Quality of Life as assessed by a questionnaire |
| Plasma solute levels | Two weeks per patient | Plasma levels of urea nitrogen and creatinine. |
Outcome results
None listed