Coronary Artery Bypass, Off-Pump, Iron Deficiencies
Conditions
Brief summary
This is a single center retrospective study of patients who underwent off pump coronary artery bypass surgery between 2016.11\ 2023.05. From this patient group, preoperatively non-anemic patients were selected and were divided into 2 cohorts according to their preoperative iron status; iron replete and iron deficient. These two cohorts were compared to evaluate the effect of preoperative iron deficiency on patient outcomes. The primary end point was the occurrence of composite morbidity/mortality end points which were: in hospital mortality, acute kidney injury (AKI), stroke, deep sternal infection, hemostatic reoperation, prolonged mechanical ventilation of more than 24hours, delirium and postoperative myocardial infarction. Occurrence of any one of these outcomes counted as primary end point met. Secondary outcome was to evaluate and compare hemoglobin recovery of iron replete and deficient patients until one year after surgery.
Interventions
None listed
Sponsors
Yonsei University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
29 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Patients who received off pump coronary artery bypass surgery (OPCAB) between 2016.11.01-2023.05.31
Exclusion criteria
* preoperative anemia (male Hb \<13g/dL, female Hb\<12g/dL) * emergency surgery * redo-off pump coronary artery bypass surgery * minimally invasive coronary artery bypass surgery * OPCAB in conjunction with other cardiac surgical procedures (e.g. valve surgery, graft replacement surgery of the aorta) * intraoperative on pump conversion * lack of sufficient preoperative data (ferritin, transferrin saturation, C-reactive protein) to determine iron status * administration of intravenous iron within 4 weeks or parenteral iron of more than 2 weeks prior to surgery * enrollemnt in other clinical studies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants with in hospital mortality, stroke, deep sternal infection, hemostatic reoperation, delirium | from the end of surgery until patient discharge (assessed up to day 60) | This outcome is a composite of the following: in hospital mortality, acute kidney injury (AKI), stroke, deep sternal infection, hemostatic reoperation, prolonged mechanical ventilation of more than 24hours, delirium and postoperative myocardial infarction. The occurrence of any one of these was regarded as primary end point met. |
| Number of participants with acute kidney injury | until 7 days after surgery | This outcome is a composite of the following: in hospital mortality, acute kidney injury (AKI), stroke, deep sternal infection, hemostatic reoperation, prolonged mechanical ventilation of more than 24hours, delirium and postoperative myocardial infarction. The occurrence of any one of these was regarded as primary end point met. |
| Number of participants with post operative myocardial infarction | until 48 hours post-surgery | This outcome is a composite of the following: in hospital mortality, acute kidney injury (AKI), stroke, deep sternal infection, hemostatic reoperation, prolonged mechanical ventilation of more than 24hours, delirium and postoperative myocardial infarction. The occurrence of any one of these was regarded as primary end point met. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Post discharge hemoglobin | Until 1 year after surgery | Data of hemoglobin levels after discharge until 1 year after surgery was collected to evaluate hemoglobin recovery to preoperative baseline levels. |
Countries
South Korea
Outcome results
None listed