Lymph Node Metastasis, Papillary Thyroid Carcinoma
Conditions
Keywords
ultrasound, deep learning, cytology
Brief summary
Rising thyroid carcinoma rates, with papillary thyroid carcinoma (PTC) as the main type (85-90% of cases), often show early cervical lymph node spread. This increases the risk of PTC patients for recurrence and death. A new study's multimodal model fuses preoperative US and cytology images to better predict lymph node metastasis, aiming to improve treatment plans, reduce unnecessary surgeries, and enhance patient outcomes.
Detailed description
Thyroid carcinoma incidence has been on the rise in recent years. Papillary thyroid carcinoma is the most prevalent type of differentiated thyroid carcinoma, accounting for 85% to 90% of malignant thyroid tumors. Despite its indolent nature, cervical lymph node metastasis is frequently observed at an early stage. Papillary thyroid carcinoma patients with cervical lymph node metastasis face an elevated risk of recurrence, distant metastasis, and mortality. Thus, non-invasive preoperative prediction of cervical lymph node metastasis is particularly vital for guiding treatment plans and prognostic. this study has developed a multimodal model integrating preoperative US images with cytological images of papillary thyroid carcinoma patients. The aim is to enhance the predictive accuracy for cervical lymph node metastasis, reduce unnecessary lymph node dissections, and provide real-time, precise guidance for determining the extent of surgical resection and prognostic assessment. This approach aims to optimize patient treatment strategies and enhance therapeutic outcomes.
Interventions
PROCEDUREThyroidectomy and lymph node dissection
All surgical specimens of thyroidectomy and lymph node dissection were subjected to paraffin-embedded histopathological examination, and postoperative were categorized as with cervical lymph node metastasis and without cervical lymph node metastasis.
Sponsors
Nanchong Central Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Inclusion criteria
* Underwent thyroidectomy and bilateral lymph node dissection with pathological confirmation of PTC * Completed US examination within one week before surgery * Underwent preoperative us-guided FNAC * Completed cytological images at 400× magnification under a microscope
Exclusion criteria
* Patients who underwent only unilateral thyroidectomy * Patients with cervical lymph nodes shown on preoperative ultrasound
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Presence or absence of lymph node metastasis | October 2024 | All surgical specimens were subjected to paraffin-embedded histopathological examination，depending on the pathological findings, it is classified as the presence or absence of lymph node metastases. |
Countries
China
Outcome results
None listed