Aging, MCI, Cognitive Decline
Conditions
Keywords
healthy aging, attention, cognition, dementia, intervention, digital, behavioral, prevention, decline, stress reduction, Quality of life
Brief summary
The goals of the proposed research are to first determine the minimal and/or optimal dose of a digital intervention required for cognitive enhancement, and then to examine the impact of several potential moderators of treatment effects (i.e., cognitive decline, AD polygenic hazard score, cardiovascular risk, and race/ethnicity). This knowledge gained from his high-impact study with transform the field of cognitive interventions, paving the way for a precision medicine model for cognitive enhancing interventions that improve quality of life for older adults and individuals with cognitive deficits at risk of developing dementia.
Interventions
DEVICEMediTrain
MediTrain is a tablet-based, meditation-inspired, cognitive training game aimed at improving self-regulation of internal attention and distractions. It was developed in collaboration with meditation thought-leader Jack Kornfield, and Zynga, a world-class video game company. It was created to make benefits of concentrative meditation more easily accessible to anyone, including complete novices. This is achieved by creating a game that yields quantifiable and attainable goals, provides feedback, and includes an adaptive algorithm to gradually increase difficulty as users improve.
DEVICEWorder
Worder was designed to enhance visual motor and visual spatial skills in individuals of all ages and cognitive abilities. Visual processing is required for all cognitive abilities that involve vision including attention, working memory, and task management. Worder's goal is to improve cognitive function more broadly by developing this critical skill underlying multiple abilities.
Sponsors
University of California, San Francisco
National Institute on Aging (NIA)
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Masking description
double blind
Eligibility
Sex/Gender
ALL
Age
60 Years to 99 Years
Healthy volunteers
Yes
Inclusion criteria
* 60+ years old (adult) * English language fluency * owning a smartphone or tablet
Exclusion criteria
* Under 60 years old (minor)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change on the Mobile Continuous Performance Task (CPT) over time | baseline, immediate follow-up, and at a 6 month follow-up | The CPT is a 23-minute task, where participants are instructed to respond to target stimuli (squares at the top of the screen) and withhold responses to non-target stimuli (squares at the bottom of the screen). Performance will be quantified as: (1) mean reaction times, (2) standard deviation of reaction times (RTV), and (3) d-prime (comparing correct target detections or 'hits' to incorrect non-target detections or 'false alarms'). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change on the Adaptive Cognitive Evaluation (ACE) over time | baseline, immediate follow-up, and at a 6 month follow-up | The ACE is a mobile cognitive assessment tool, which includes a battery of cognitive control tests for rapid tests of cognition. The sub-tests (or 'modules') in ACE are adapted from standardized tasks to rapidly assess various aspects of cognition, including attention, memory, and multitasking. We will assess response time, accuracy, and response time variability in each case, with faster/more accurate/less variable performance being indicative of improved cognitive control. |
Countries
United States
Contacts
CONTACTDavid Ziegler, PhD
CONTACTMonique de Villa, MS, MPH
PRINCIPAL_INVESTIGATORAdam Gazzaley, MD/PhD
University of California, San Francisco
PRINCIPAL_INVESTIGATORDavid Ziegler, PhD
University of California, San Francisco
Outcome results
None listed