Hepato-Biliary Neoplasm, Nutritional Support, Postoperative
Conditions
Keywords
nutritional support, Hepato-Biliary Neoplasm, postoperative curation
Brief summary
A comprehensive comparative analysis of the effectiveness of isolated enteral, isolated parenteral and mixed type of nutritional support in the early postoperative period in patients after operations performed on the malignant neoplasms of hepatico-pancreatico-duodenal zone.
Detailed description
A prospective, longitudinal, parallel study and retrospective analysis of the results of treatment of 91 patients with malignant tumors of the hepatico-pancreato-duodenal zone who underwent the following operations: 1. resection of various segments of the liver; 2. hemihepatectomy; 3. transhepatic drainage of the right and left hepatic duct; 4. bypass gastroenteroanastomosis or cholecystenteroanastomosis with interintestinal enteroenteroanastomosis according to Brown; 5. gastro-pancreato-duodenal resection; 6. corpore-caudal resection of the pancreas with splenectomy. The first group (n=31) included patients who received enteral nutrition (EN) after surgery. The second group (n=30) included patients who received parenteral nutrition (PN) and the third group (n=30) who received mixed nutrition (MN), as a variation of the partial parenteral nutrition technique, in the early postoperative period. Some nutritional status indicators available for determination at the Oncology Clinic were assessed - body mass index (weight measurements were carried out before surgery, on the 5th, 10th and 15th days), basal metabolic rate (calculated using the Harris-Benedict equation, based on anthropometric data of the patient (gender, age, weight and height).), laboratory parameters: blood hemoglobin, lymphocytes, total protein, serum albumin, serum transferrin, total bilirubin and direct, alanine aminotransferase (ALT), aspartate aminotransferase (AST), which are related to the traditional method for assessing nutritional status
Interventions
DIETARY_SUPPLEMENTparenteral nutrition supplements
parenteral nutrition
DIETARY_SUPPLEMENTenteral nutrition supplements
enteral nutrition
DIETARY_SUPPLEMENTmixed nutrition supplements
mixed nutrition
Sponsors
Karaganda Medical University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Intervention model description
prospective, longitudinal, parallel study
Eligibility
Sex/Gender
ALL
Age
20 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
female and male patients in age of 20-75 with malignant tumors of the hepato-pancreato-duodenal zone who have undergone any of the following operations: 1. resection of various segments of the liver; 2. hemihepatectomy; 3. transhepatic drainage of the right and left hepatic duct; 4. bypass gastroenteroanastomosis or cholecystoenteroanastomosis with interintestinal enteroenteroanastomosis according to Brown; 5. gastro-pancreatoduodenal resection; 6. corporecaudal resection of the pancreas with splenectomy.
Exclusion criteria
* patients in age of up to 20 and older than 75 * pregnant and breastfeeding women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of Participants with changes of BMI in kg/m^2 | Day 0, Day 5, Day 10, Day15 | Variables of Body mass index measured by Canadian Guidelines for Body Weight Classification in Adults |
| Basal Metabolic rate | Day 0, Day 5, Day 10, Day15 | basal metabolic rate according to the Harris-Benedict equation |
| Total protein level in Blood | Day 0, Day 5, Day 10, Day15 | Blood biochemical analysis: total protein in g/L |
| Serum albumin in g/L | Day 0, Day 5, Day 10, Day15 | Blood biochemical analysis: serum albumin in g/L |
| Serum transferrin in g/L | Day 0, Day 5, Day 10, Day15 | Blood biochemical analysis: serum transferrin in g/L |
| Total bilirubin in mmol/L | Day 0, Day 5, Day 10, Day15 | Blood biochemical analysis: total bilirubin in mmol/L |
| Direct bilirubin in mmol/L | Day 0, Day 5, Day 10, Day15 | Blood biochemical analysis: direct bilirubin in mmol/L |
| ALT in IU/L | Day 0, Day 5, Day 10, Day15 | Blood biochemical analysis: ALT in IU/L |
| AST in IU/L | Day 0, Day 5, Day 10, Day15 | Blood biochemical analysis: AST in IU/L |
Countries
Kazakhstan
Outcome results
None listed