Preeclampsia
Conditions
Brief summary
Preeclampsia is a major devastating disorder affects 2:10% of pregnancies worldwide. preeclampsia may be associated with placental insufficiency which may cause fetal blood redistribution to essential organs like brain, heart, kidney.
Detailed description
Preeclampsia is a major devastating medical condition that affects pregnant women after 20 weeks of pregnancy. It affects 2:10% of pregnancies worldwide according to World Health Organisation with higher incidence in developing countries. Vascular endothelial dysfunction due to abnormal placentation is believed to be the main cause of multi-organ failure and uteroplacental insufficiency that occur in preeclampsia leading to major adverse effects in both mother and fetus. Placental insufficiency causes a redistribution of fetal blood to essential organs ; brain, heart and adrenal glands by decreasing their vascular resistance on expense of peripheral organs. Changes occur in fetal renal circulation in preeclampsia is still area of debate with conflicting results in literature. Doppler ultrasound examination of vasculature of selected organs such as kidneys may have a role in detection of hemodynamic rearrangements that occur in cases of placental insufficiency and preeclampsia. Also, Three dimensional power Doppler plays a role in comprehensive analysis of placental perfusion. It has a promising results regarding prediction of preeclampsia during early pregnancy and may have insights into prediction of adverse neonatal outcomes in late trimester.
Interventions
OTHERfetal ultrasound
2D, 3D , Doppler ultrasound
Sponsors
Assiut University
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
Yes
Inclusion criteria
* a) Preeclampsia: * Women with preeclampsia \>28 weeks of pregnancy. * Singleton pregnancy. * Women with intrauterine growth restriction and abnormal amniotic fluid volume to simulate real world data. b) Control: * Women with healthy pregnancy matched by closest gestational age.
Exclusion criteria
* ● Multiple pregnancy. * Known Congenital fetal malformations. * Women with other comorbidity such as ischemic heart disease, DM, Autoimmune disorders, kidney disease, neurological disorders, liver or haematological disorders. * Women unable to provide informed consent. * Women who refuse to participate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| fetal renal artery doppler indices | 1 year | the difference between the Fetal renal artery Doppler indices between preeclamptic patients and women with healthy pregnancy |
| Middle cerberal artery doppler indices , Umbilical artery doppler indices and placental volume | 1 year | — |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| neonatal outcome | 1 year | the ability of Fetal renal artery Doppler in prediction of neonatal complications. |
Countries
Egypt
Contacts
PRINCIPAL_INVESTIGATORYousra O Mokhtar
principle investigator
Outcome results
None listed