Atrophy of Edentulous Alveolar Ridge
Conditions
Keywords
CAD-CAM bone blocks, hyaluronic acid, histomorphometric analysis
Brief summary
Each patient will receive 2 prefabricated CAD-CAM allogeneic bone blocks sterilized with gamma rays with different rehydration methods. Side I: prefabricated CAD-CAM allogeneic bone block sterilized with gamma rays hydrated using hyaluronic acid \* Side II: prefabricated CAD-CAM allogeneic bone block sterilized with gamma rays hydrated using saline solution Both blocks are fixed with osteosynthesis screws, covered with non resorbable membranes\*\* The membranes will be removed after 6 months, dental implants will be placed and core biopsy will be collected from the site of the implant placement for histologic evaluation
Detailed description
10 patients will be included in this study with bilateral atrophic posterior mandible for split mouth research . group I: prefabricated CAD-CAM allogeneic bone block sterilized with gamma rays hydrated using hyaluronic acid group II: prefabricated CAD-CAM allogeneic bone block sterilized with gamma rays hydrated using saline solution under LA mucoperiosteal flap will be elevated to expose the atrophic ridge then the prefabricated CAD-CAM allogenic block either mixed with hyaluronic acid (group I) or saline (group II) will be fixed in its position with titanium miniscrews , The block was coated with a nonporous d-PTFE membrane then closure of flap with nylon second stage: 6 months later exposure of alveolar ridge core biopsy was taken for histological study then insertion of titanium implants. the aim of the study is to investigate the effect of hyaluronic acid on a prefabricated CAD- CAM bone blocks for ridge augmentation radiographically and histologically.
Interventions
PROCEDUREprefabricated CAD-CAM allogeneic bone block hydrated using hyaluronic acid
exposure of atrophic posterior mandibular ridge, augmentation with CAD-CAM prefabricated allogenic bone block which fixed with titanium screws ,The block was coated with a nonporous d-PTFE membrane
PROCEDUREprefabricated CAD-CAM allogeneic bone block sterilized hydrated using saline solution
exposure of atrophic posterior mandibular ridge, augmentation with CAD-CAM prefabricated allogenic bone block which fixed with titanium screws. The block was coated with a nonporous d-PTFE membrane
Sponsors
Tanta University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Masking description
using closed envelop for participants the data will be given to outcomes assessors without defining the intervention for each group
Intervention model description
parallel assignment
Eligibility
Sex/Gender
ALL
Age
40 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients between 40 to 65 years old. * Posterior atrophic mandibular ridge indicated for horizontal and vertical ridge augmentation for dental implant placement. * Good oral hygiene
Exclusion criteria
* Systemic diseases that affect host healing responses. * Heavy smoking. * Poor oral hygiene. * Traumatic occlusion, sever para-functional habits (ex. bruxism, clenching,)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the amount of new bone formation | 6 months | core biopsy will be underwent histomorphometric analysis to determine the percentage of new bone formation (%) |
| measurement the width and the height of the alveolar ridge | 6 months | using CBCT the width and the height will be measured with measuring tools in milimeter (mm) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| the sucess of dental implants | 12 months | usingCBCT to determine the amount of marginal bone loss in (mm) |
Countries
Egypt
Outcome results
None listed