Ascorbic Acid Deficiency, Transplantation
Conditions
Keywords
Transplantation, Ascorbic Acid, Oxidative Stress, Primary Graft Dysfunction
Brief summary
The objective of this observational clinical study is to evaluate the variations in ascorbic acid during the transplantation phases and how these variations influence the oxidative status and patient outcome. The main questions it aims to answer are: * how many patients arrive at the transplant in a state of hypovitaminosis C? * how does hypovitaminosis C affect the patient's oxidative status? * how does hypovitaminosis C affect the length of stay in intensive care and post-transplant complications?
Detailed description
Researches will compared: Differences between Hypovitaminosis Group and Normal Range Group Changes in oxidative stress markers before and after solid organ transplantation Incidence of allograft dysfunction between groups Incidence of acute kidney injury and other complications between groups
Interventions
None listed
Sponsors
Policlinico Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients undergoing solid organ transplantation (liver or kidney or lung)
Exclusion criteria
* Minor patients * Multi-organ transplantation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ascorbic Acid levels | At induction of anesthesia for TX, within 24h from ICU admission, 72 hours after transplantation, 7 days after transplantation | Quantification of plasma ascorbic acid levels before and after liver/kidney/lung transplantation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Total Antioxidant Capacity (TAC) levels | At induction of anesthesia for TX, within 24 hours from ICU admission, 72 hours after transplantation, 7 days after transplantation | Quantification of TAC before and after liver/kidney/lung transplantation |
| 8-hydroxydeoxyguanosine (8-OHdG) levels | At induction of anesthesia TX, within 24 hours from ICU admission, 72 hours after transplantation, 7 days after transplantation | Quantification of 8-OHdG before and after liver/kidney/lung transplantation |
| Mechanical ventilation | From ICU admission until extubation occurs, assessed daily up to 100 days from transplantation | Duration of mechanical ventilation (days) until extubation of the recipient |
| Length of Intensive Care Unit (ICU) stay | From ICU admission until ICU discharge occurs, assessed daily up to 100 days from transplantation | Length of ICU stay |
| Reactive Oxygen Species (ROS) levels | At induction of anesthesia for TX, within 24 hours from ICU admission, 72 hours after transplantation, 7 days after transplantation | Quantification of ROS before and after liver/kidney/lung transplantation |
| Mortality in Intensive Care Unit (ICU) | From ICU admission until ICU discharge occurs, assessed daily up to 100 days from transplantation | Incidence of death for any cause during ICU stay |
| Length of hospitalization | From ICU admission until hospital discharge occurs, assessed daily up to 100 days from transplantation | Length of stay in hospital (days) |
| Acute kidney injury (AKI) | Worst kidney function within the first 7 days after TX | Incidence of postoperative renal injury after liver/kidney/lung transplantation as Kidney Disease Improving Global Outcomes (KDIGO) criteria |
| Allograft dysfunction | Within the first 7 days after transplantation | Incidence of early allograft dysfunction (EAD in liver recipients), primary graft dysfunction (PGD in lung recipients), delayed graft function (DGF in kidney recipients) |
Countries
Italy
Outcome results
None listed