Cardio-fistular Recirculation in Patients With Chronic Heart Failure and Preserved Left Ventricle Ejection Fraction

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06394986

Enrollment

Registered

2024-05-01

Start date

2018-06-18

Completion date

2019-02-18

Last updated

2024-05-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Kidney Disease 5D, Heart Failure, Heart Failure NYHA Class I, Heart Failure NYHA Class II

Keywords

arteriovenous fistula, hemodialysis, cardiac output, heart failure, volume blood flow, cardio-fistular recirculation, cardiopulmonary recirculation, ejection fraction

Brief summary

This is a single-arm cohort study aimed to evaluate change of arteriovenous fistula volume blood flow / cardiac output ratio in patients with chronic heart failure (NYHA I-II classes) and with preserved ejection fraction as a result of a hemodialysis session after a long interdialysis interval.

Interventions

PROCEDUREHemodialysis session

Change of arteriovenous fistula volume blood flow / cardiac output ratio in patients with chronic heart failure (NYHA I-II classes) and with preserved ejection fraction as a result of a hemodialysis session will be explored.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* signed informed consent, * \> 18 years * maintenance (chronic) hemodialysis, * native arteriovenous fistula, * arteriovenous fistula volume blood flow ≥1 l/min, * arteriovenous fistula volume blood flow / cardiac output ratio \< 0.3, * interdialysis weight gain \<5% of dry body weight, * sufficient hemodialysis dose (eKt/V \> 1.2), * chronic heart failure (NYHA I-II classes only), * preserved left ventricular ejection fraction (≥50%), * absence of arrhythmias (except first-degree atrioventricular block block), * absence of heart valve disease (except mitral regurgitation grade I-II), * absence of intradialysis hypo/hypertension * long interdialysis interval (3 days).

Exclusion criteria

* hypo/hypertension during or after hemodialysis, * arrhythmias (except first-degree atrioventricular block) after hemodialysis.

Design outcomes

Primary

Measure	Time frame	Description
Change in cardio-fistular recirculation	One hour before and two hours after the hemodialysis session.	Change in arteriovenous fistula volume blood flow / cardiac output ratio

Countries

Russia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026