Abdominal Surgery, Laparoscopic Surgery
Conditions
Keywords
Abdominal surgery, Laparoscopic surgery, Dexmedetomidine, Opioid free anesthesia
Brief summary
Effectiveness of opioid free anesthesia using Dexmedetomidine to inhibit nociception in abdominal laparoscopic surgery
Detailed description
Abdominal laparoscopic surgery is one of the most common procedures worldwide, commonly facilitated with opioid balanced anesthesia or regional anesthesia. Despite being a controversy, there are issues that suggest opioid to have an influence in tumor recurrence. The investigators performed general anesthesia without opioid in laparoscopic abdominal surgery, and compared the hemodynamic instability, total consumption of fentanyl rescue, qNOX score, Ephedrine intraoperative, and Numerical Rating Scale.
Interventions
DRUGDexmedetomidine
OFA
DRUGFentanyl
Given as analgesia in opioid balanced anesthesia (control) group
Sponsors
Indonesia University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Intervention model description
Participants are randomized into two groups for control (opioid balanced anesthesia) or intervention (opioid free anesthesia)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Patients undergoing abdominal laparoscopic surgery (digestive, urologic, gynecologic surgery) with general anesthesia * BMI \<= 30 kg/m2 * Assessed with ASA 1-3 * Willing to participate in this study
Exclusion criteria
* Allergy to dexmedetomidine * Heart rate \< 60 or systolic blood pressure \<100 mmHg * Severe cardiovascular, uncontrolled hypertension (stage 2) or hepatic or renal disorder * Sepsis * Pregnancy * Difficult airway Drop out Criteria: * Intraoperative emergency * Convert to open laparatomy * Decided to withdraw from the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood pressure | Intraoperative | blood pressure, both systolic and diastolic measured with non invasive blood pressure monitoring |
| Heart rate | Intraoperative | Heart rate |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pain score | 24 hour | Numerical rating scale 0-10 is used to quantify pain score postoperatively, with higher value indicating more pain experienced by the patient |
| Total consumption of Opioid | Intraoperative | Total consumption of fentanyl as rescue analgesia in mcg |
| quantium nociception index (qNOX) | Intraoperative | qNox score is measured at specific time points, available from Conox monitor measurement since the start of the procedure. Higher value indicates more nociception experienced by the patient (0-100) |
| Ephedrine | intraoperative | Total consumption of ephedrine to increase heart rate and blood pressure in mg |
Countries
Indonesia
Outcome results
None listed