Percutaneous Nephrolithotomy
Conditions
Keywords
fever, gram stain, percutaneous nephrolithotomy, Systemic inflammatory response syndrome (SIRS)
Brief summary
In this study, investigators compared the systemic inflammatory responses after percutaneous nephrolithotomy (PCNL) patients who were given an expanded empirical antibiotic regimen based on the prediction of the possibility of bacteria identified by Gram staining the first urine after renal puncture and patients whose antibiotic regimen was not performed and whose antibiotic regimen was adjusted according to patient symptoms and culture results. Investigators aimed to test its diagnostic value in predicting and preventing complications.
Interventions
DIAGNOSTIC_TESTGram staining of the first urine after intraoperative renal puncture to predict the systemic inflammatory response after percutaneous nephrolithotomy.
Gram staining of the first urine after intraoperative renal puncture to predict the systemic inflammatory response after percutaneous nephrolithotomy.
Sponsors
Adiyaman University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Intervention model description
The patients included in the study were randomized by a block randomization method by an independent researcher, hidden from the patients and the responsible clinicians, using a computerized number tool.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients with an indication for percutaneous nephrolithotomy due to kidney stone disease.
Exclusion criteria
* under 18 years old, * having an active urinary tract infection before surgery and positive urine cultures, * Patients with bilateral kidney stones, * DJ stent or nephrostomy placement, * Solitary kidney stones, * Bleeding disorders, * impaired kidney function, * a history of antibiotic use for any reason within 2 weeks before randomization were excluded from the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Efficacy of Gram stain in predicting systemic inflammatory response after percutaneous nephrolithotomy. | immediately after the surgery | Gram staining of urine after puncture to detect the presence of bacteria that are a possible source of infection according to the rate of gram-stained and non-gram-stained patients by microscopic examination. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of antibiotic regimen after bacterial estimation of Gram stain | immediately after the surgery | The percentage of patients whose antibiotic regimen was changed by estimating bacteria after Gram staining did not progress to systemic inflammatory response syndrome. Systemic inflammatory response criteria: temperature less than 36 °C or higher than 38 °C, heart rate more than 100 beats per minute, respiratory rate more than 20 per minute, leukocyte count greater than 12 × 10 up 9/L or 4 × 10 up 9/L less than L, systolic blood pressure falling below 90 mmHg, or diastolic blood pressure falling below 40 mmHg |
Countries
Turkey (Türkiye)
Contacts
Primary ContactBedreddin Kalyenci
Outcome results
None listed