Hemodialysis Complication
Conditions
Keywords
ketoacid analogues, inflammation, hemodialysis
Brief summary
this study tries to measure the effect of intradialytic ketoacid analogues on inflammatory parameters
Detailed description
this study will measure inflammation parameters: * interleukin 6 * malnutrition inflammation score * neutrophil lymphocyte ratio * monocyte lymphocyte ratio * thrombocyte lymphocyte ratio the duration of intervention is 12 weeks
Interventions
DRUGKetoacid
250 ml ketoacid two hours before the hemodialysis session ended
Sponsors
RSUP Fatmawati
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
intervention and control
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* patient who undergo hemodialysis two times a week
Exclusion criteria
* travelling hemodialysis * acute conditions * HIV patient * acute infection * stroke and immobilized patient
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| interleukin-6 | 12 weeks | in pg/mL, no limit values |
| malnutrition inflammation score | 12 weeks | consists of ten components, based on subjective complaints combined with albumin serum (in g/dL), serum iron (in micromol/L, and total iron binding capacity (in micromol/L). the sum of all components \>5 means have high inflammation status |
| neutrophil lymphocyte ratio | 12 weeks | the percentage ratio of neutrophil count and lymphocyte count will be combined to neutrophil lymphocyte ratio |
| monocyte lymphocyte ratio | 12 weeks | the percentage ratio of monocyte count and lymphocyte count will be combined to monocyte lymphocyte ratio |
| thrombocyte lymphocyte ratio | 12 weeks | the percentage ratio of thrombocyte (in per microliter of blood) and lymphocyte count will be combined to thrombocyte lymphocyte ratio |
Countries
Indonesia
Outcome results
None listed