Neuroinflammation
Conditions
Brief summary
The prospective observational study delves into the complex relationship between neuroinflammation and oxidative stress in post-cardiac surgery complications, focusing on postoperative cognitive dysfunction.
Detailed description
The prospective observational study meticulously examines the interplay between neuroinflammation and oxidative stress in the realm of post-cardiac surgery complications, specifically targeting postoperative cognitive dysfunction. Its primary objective is to comprehensively assess the sustained influence of these intricate processes on cognitive function and overall well-being, extending beyond the immediate aftermath of surgery. The research endeavors to probe deeply into the molecular mechanisms and clinical ramifications associated with neuroinflammation and oxidative stress, centering on their pivotal role in shaping the onset and trajectory of postoperative cognitive dysfunction.
Interventions
OTHERextracorporeal circulation
extracorporeal circulation during cardiosurgical operation
Sponsors
East Slovak Institute for Cardiovascular Diseases
Europainclinics z.ú.
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Inclusion criteria
* Undergoing cardiosurgical operation * Absence of previous neurological disease * Signed informed consent document
Exclusion criteria
* Presence of neoplasms * Neurological Disease * Refusal to participate in the clinical trial
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number and type of early complications after surgery | 1 month | Estimating of postoperative complications |
| Number and type of postoperative complications | 6 months | Estimating of postoperative complications |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Estimating biochemical parameters | 1 hour | Pro-inflammatory interleukins parameters (e.g. IL-8, IL-6, MIP-1a, MMP-2, MMP-9, SIRT 1, SIRT 2) |
| Estimating biochemical parameters Third biochemical examination | 1 hour | Antioxidative enzymes |
Countries
Slovakia
Contacts
Primary ContactLadislav Kočan, MD, PhD, FIPP
Backup ContactJanka Vašková, prof. Dr. PhD.
Outcome results
None listed