Diagnosis
Conditions
Keywords
uterine artery, apelin-13, apelin-36, Doppler
Brief summary
This study was conducted to investigate the relationship between diastolic notching on uterine artery Doppler and serum apelin-13 and 36 concentrations between 11 and 14 weeks of gestation.
Detailed description
Apelin-13 and apelin-36, which provide vasodilatation through a nitric oxide-dependent mechanism, also play a role in trophoblasts' survival, proliferation, and migration. Based on this, we aimed to investigate serum apelin-13 and apelin-36 concentrations in pregnant women with and without diastolic notch on uterine artery Doppler between the 11th and 14th weeks of pregnancy. We hypothesized that apelin-13 and apelin-36 might be associated with the formation of diastolic notch in uterine artery Doppler and serum apelin-13 and apelin-36 concentrations would be lower in the group with a notch in the uterine artery Doppler than in the group without a notch.
Interventions
OTHERno intervention
there is no intervention in this study
Sponsors
Umraniye Education and Research Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 39 Years
Healthy volunteers
Yes
Inclusion criteria
1. Nonsmokers, 2. Singleton pregnancies between 11 and 14 weeks of gestation 3. Pregnant women who did not conceive with assisted reproductive methods
Exclusion criteria
1. Smokers 2. Pregnant women who conceived with assisted reproductive techniques 3. Pregnant women with multiple pregnancies 4. Pregnant women who started with multiples and continued with singletons 5. Pregnant women with any pregestational disease, thrombophilia 6. Pregnant women with any congenital uterine anomaly 7. Pregnant women with a history of recurrent pregnancy loss 8. Pregnant women using aspirin or heparin
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Relationship between diastolic notching on uterine artery Doppler and serum apelin-13 and apelin-36 concentrations. | through study completion, an average of 1 year | Relationship between diastolic notching on uterine artery Doppler and serum apelin-13 and apelin-36 concentrations. |
| Relationship between high pulsatility index on uterine artery Doppler and serum apelin-13 and apelin-36 concentrations. | through study completion, an average of 1 year | Relationship between high pulsatility index on uterine artery Doppler and serum apelin-13 and apelin-36 concentrations. |
Countries
Turkey (Türkiye)
Outcome results
None listed