Is Low Flow Anaesthesia Feasible?

Low Flow Anaesthesia is Good But Feasible?

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06389669

Enrollment

785

Registered

2024-04-29

Start date

2024-05-23

Completion date

2024-09-20

Last updated

2024-10-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia

Keywords

Low Flow Anaesthesia, Closed-Circuit Anesthesia

Brief summary

Although low-flow anaesthesia (LFA) has been described for many years and its benefits are known, its clinical use has been limited. Concerns about the risk of hypoxia contributed to this situation. Although the risk of hypoxia is almost prevented with advanced anaesthesia machines, the use of LFA has not reached the desired levels. However, in recent years, as adverse developments related to climate change have started to affect us all, LFA has started to be on the agenda of anaesthetists again. In this study, our aim is to examine the feasibility of its clinical use in order to popularise the use of LFA.

Detailed description

ASA 1-2 patients who will undergo elective surgery under general anaesthesia in 38 operating rooms of Inonu University Faculty of Medicine will be prospectively recruited for 3 months (May-June-July). Emergency cases, patients under the age of 18 and over 65, laparoscopic surgeries, heart-lung surgeries that may impair oxygenation will not be included in the study. Inhaler anaesthesia will be administered after anaesthesia induction and tracheal intubation. Fresh gas flow (FGF) will be determined as 1 l/min, MAC=1, FiO2=40% with target controlled automatic gas control mode (AGC). FGF will be decreased to 0.5 l/min 10 minutes after surgical incision, if successful, it will be decreased to 0.3 l/min 10 minutes later and it will be checked whether it is successful. The study will be terminated and FGF will be increased to 1 l/min again. Demographic data of the patients and FGF levels that can provide FiO2=40% will be recorded.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Patients undergoing surgery under general anaesthesia

Exclusion criteria

* Emergency operations * Previously diagnosed heart, lung, liver and kidney disease * Surgeries that may impair oxygenation (laparoscopic, Heart, Lung surgeries)

Design outcomes

Primary

Measure	Time frame	Description
Feasibility of Low Flow Anaesthesia	The measurement will start 10 minutes after the surgical incision and end 20 minutes later	To determine the lowest amount of fresh gas flow, most suitable for the patient and, which can provide FiO2=40% level

Secondary

Measure	Time frame	Description
Factors affecting oxygen consumption	The measurement will start 10 minutes after the surgical incision and end 20 minutes later	To find out which of the patient's physical characteristics that affect oxygen consumption may be determinant.

Countries

Turkey (Türkiye)

Outcome results