Epilepsy, Epilepsy, Idiopathic Generalized
Conditions
Brief summary
The idiopathic generalized epilepsies (IGEs) have historically included the syndromes childhood absence epilepsy (CAE), juvenile absence epilepsy (JAE), juvenile myoclonic epilepsy (JME), and epilepsy with generalized tonic-clonic seizures alone (GTCA). Recognition of the IGEs is important for clinical care, as it informs diagnosis, prevents unnecessary investigation, allows optimal selection of anti-seizure medications (ASMs), and provides prognostic guidance. According to the new ILAE definition in 2022, the study aims to describe the clinical features, electroencephalographic, imaging findings and long-term prognosis.
Detailed description
the Long-term prognosis include the rate of drug-resistent epilepsy, relapse after drug withdrawn, common comorbidities such as mood disorders, attention deficit hyperactivity disorder (ADHD) and learning disabilities.
Interventions
None listed
Sponsors
Shen Chun-Hong
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
4 Years to 40 Years
Inclusion criteria
* Patients are consecutively and prospectively enrolled from epilepsy center, with newly diagnosed epilepsy or established epilepsy. * Patients have a diagnosis of idiopathic generalized epilepsy (IGE), according to the 2022 diagnostic criteria. * Comprehensive clinical information is collected, and 24 hour video-electroencephalography is performed. * Sign the informed consent forms.
Exclusion criteria
* Other epilepsy syndromes are considered during follow-up, such as genetic generalized epilepsy. * Lost to follow-up
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The proportion of drug-resistent epilepsy | through study completion, an average of 1 year | We defined drug-resistant cases as those patients who have failed two or more trials of broad-spectrum ASMs or those otherwise indicated in IGE syndromes |
| The proportion of seizure freedom | through study completion, an average of 1 year | We defined seizure freedom according to the International League Against Epilepsy (ILAE) definition |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The proportion of psychiatric comorbidity | through study completion, an average of 1 year | The psychiatric comorbidities mainly include anxiety and depression, which are evaluated by Hamilton anxiety scale and Hamilton depression scale, respectively. |
| The proportion of psychosocial outcome | through study completion, an average of 1 year | such as university entrance, marry |
| The proportion of seizure relapse after antiseizure medication withdrawn | through study completion, an average of 1 year | Antiseizure medication withdrawn should be recommended by epilepsy experts |
Countries
China
Contacts
Primary ContactChunhong Shen
Outcome results
None listed