Healthy
Conditions
Brief summary
This study investigates how different low-carbohydrate diets affect metabolism and hunger in overweight adults. We will measure metabolic rates and blood metabolites.
Detailed description
Participants will engage in three distinct eating plans: a standard diet with usual carbohydrate and calorie levels, a low-carb diet with typical calories, and a low-carb diet with reduced calories. Each diet is followed for a single day, with subsequent monitoring to assess how the body processes food and manages hunger after a meal. The goal is to understand the potential metabolic benefits of reducing carbohydrate intake, either alone or in combination with calorie reduction. This research aims to identify simpler dietary strategies that could improve heart health and assist in weight management without the need for severe calorie restriction or fasting, offering valuable insights for enhancing health outcomes in overweight individuals.
Interventions
OTHERnEB Diet, followed for 36 hours
nEB diet first, then LC25 and LCEB in random order with a 5 days washout between each diet
OTHERLC25 Diet, followed for 36 hours
LC25 diet first, then nEB and LCEB in random order with a 5 days washout between each diet
OTHERLCEB Diet, followed for 36 hours
LCEB diet first, then LC25 and nEB in random order with a 5 days washout between each diet
Sponsors
University of Surrey
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* stable weight within ±3 kg over the past three months * no significant medical history.
Exclusion criteria
* pregnancy * breastfeeding, * using medications that could affect the study's outcomes * high intake of caffeine and alcohol * existing eating or psychiatric disorders * adherence to strict dietary regimens like veganism * high BMI resulting from significant muscle mass
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Biomarkers in blood Measured | 8 hours (fasting and post-meal) | Measured with ELISA assay and clinical analyser (INDIKO) |
| Resting metabolic rate | 8 hours (fasting and post-meal) | Measured with indirect calorimetry (GEM) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Perceived Appetite Scores | 8 hours (fasting and post-meal) | Measured with a Visual Analog Scale |
| Food intake | baseline and after each diet arm for 1 day | Measured using food diaries |
Countries
United Kingdom
Outcome results
None listed