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Effect of Different Irrigation Solutions on Postoperative Pain and Lesion Healing

Evaluation of the Effects of Different Irrigation Solutions Used in Regenerative Endodontic Treatment of Lower Molars With Open Necrotic Apexes on Postoperative Pain and Lesion Healing

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06386991
Enrollment
39
Registered
2024-04-26
Start date
2024-01-01
Completion date
2026-01-01
Last updated
2024-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endodontic Disease

Brief summary

In this study researchers plan to conduct, three different irrigation solutions that are responsible for the release of growth factors necessary for the success of regenerative endodontic treatments will be used. These solutions; Ethylene Diamine Tetra Acetic Acid (EDTA), Etidronic Acid and Citric Acid. The aim of this study is to evaluate the effect of different irrigation solutions used in regenerative endodontic treatment of necrotic open apex molar teeth on postoperative pain. Additionally, the healing of these teeth will be monitored for 1 year.

Detailed description

Root canal treatment is a treatment method applied to milk and permanent teeth. The inflamed and necrotic pulp where the root canal is located is cleaned, debrided chemo-mechanically, and finally filled hermetically with a biocompatible material. Necrotic immature teeth lose their restorative and defensive abilities. Since the root canal walls of these teeth are thin and weak, regenerative endodontic procedures are applied more frequently in the treatment of immature teeth to ensure root development and to restore the vitality of the pulp tissue. In this study researchers plan to conduct, three different irrigation solutions that are responsible for the release of growth factors necessary for the success of regenerative endodontic treatments will be used. These solutions; Ethylene Diamine Tetra Acetic Acid (EDTA), Etidronic Acid and Citric Acid. The aim of this study is to evaluate the effect of different irrigation solutions used in regenerative endodontic treatment of necrotic open apex molar teeth on postoperative pain. Additionally, the healing of these teeth will be monitored for 1 year.

Interventions

OTHERUsing ethylenediaminetetraacetic acid (EDTA), citric acid ((MONO/ANH) and etidronic acid (HEBP) to clean root canals during regenerative endodontic treatments

Regenerative endodontic treatment using different irrigation solutions

Sponsors

TC Erciyes University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
ALL
Age
8 Years to 15 Years
Healthy volunteers
Yes

Inclusion criteria

• Molars with open apex * Teeth with apical periodontitis * Teeth for which prosthetic restoration is not planned * Patients between the ages of 8-15 who do not have any significant health problems * Patients who are not accompanied by periodontal problems and have good oral hygiene

Exclusion criteria

• People with systemic disease and allergic reactions * Severely damaged teeth * If the tooth has previously undergone root canal treatment. * Use of antibiotics, anti-inflammatory and painkillers in the last two weeks

Design outcomes

Primary

MeasureTime frameDescription
Determining and recording pain levels on the pain scale between treatment sessions2 weeksEvaluations close to 100 on the postoperative pain scale indicate that the severity of pain increases. Evaluations close to 0 indicate that the severity of pain has decreased.

Secondary

MeasureTime frameDescription
In the follow-up sessions after the treatment, the size of the lesion in the bone (mm2) is measured by radiography.2 yearsEvaluations close to 100 on the scale following lesion healing indicate that the lesion size has increased. Evaluations close to 0 indicate that the lesion size has decreased.

Countries

Turkey (Türkiye)

Contacts

Primary ContactERASLAN AKYÜZ
ipekemamak@hotmail.com4447138
Backup ContactÜSTÜN
yustun@erciyes.edu.tr4447138

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 6, 2026