Brain Activity, Cognitive Change, Nutrition, Healthy
Conditions
Brief summary
The aim of the present study is to investigate the effects of different meal interventions on cognition (i.e., learning and decision making) and brain activity in healthy participants.
Interventions
OTHERDietary intervention: Standardized breakfast with varying amounts of macronutrients (in particular carbohydrate/protein ratios)
Participants receive a standardized meal with one type of macronutrient composition in one experimental session and the other type in a different experimental session a few days apart (within-subjects crossover design; i.e. order counterbalanced)
Sponsors
Medical University of Vienna
University of Vienna
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* 18 to 40 years old * fluent in German * right-handed * able to safely undergo MRI scanning * BMI (Body-Mass-Index) between 18.5 and 29.9 kg/m2
Exclusion criteria
* current medication that might interfere with the processes studied * any metabolic, gastrointestinal, cardiological, neurological, psychiatric or any recurring or chronic diagnoses * drug use * alcohol consumption \> 10 g/d for women and \> 20 g/d for men * smoking * shifted circadian rhythm (e.g. jetlag, shift work) * vegan or vegetarian diet * food intolerances * females: hormonal contraception, pregnancy, lactation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in cognition/behavior I | 3-4.5 hours (post-meal) | Changes in learning behavior assessed via computer-based learning task (predictive inference task) which tracks choices and response times (allows for calculation of learning-related scores: change in prediction choice following feedback) |
| Changes in cognition/behavior II | 3-4.5 hours (post-meal) | Changes in decision-making behavior assessed via computer-based decision task (gamble task) which tracks choices (calculation of gamble acceptance frequencies) and response times. |
| Changes in brain activity | 3-4.5 hours (post-meal) | Changes in brain activity measured via functional magnetic resonance imaging; |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in metabolic parameters III | from baseline (prior meal) to approx. 4.5 hours after meal at several time points | Changes in the concentrations of insulin (assessed via blood samples and chemical analysis) |
| Changes in metabolic parameters IV | from baseline (prior meal) to approx. 4.5 hours after meal at several time points | Changes in the concentration of cortisol (assessed via saliva samples and chemical analysis) |
| Changes in experienced hunger | rom baseline (prior meal) to approx. 4.5 hours after meal at several time points | Changes in subjective reported hunger (assessed via single-item Likert-Scale) |
| Changes in subjective affective state | from baseline (prior meal) to approx. 4.5 hours after meal at several time points | Changes in reported affect (Multidimensionaler Befindlichkeitsfragebogen - multidimensional mood scale; Steyer et al., 1997) |
| Changes in metabolic parameters I | from baseline (prior meal) to approx. 4.5 hours after meal at several time points | Changes in the concentrations of amino acids (assessed via blood samples and chemical analysis) |
| Changes in metabolic parameters II | from baseline (prior meal) to approx. 4.5 hours after meal at several time points | Changes in the concentrations of glucose (assessed via blood samples and chemical analysis) |
Countries
Austria
Contacts
Primary ContactStefan Schulreich, Prof. Dr.
Outcome results
None listed