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Effect of Oliceridine on Rebound Pain

A Clinical Study on the Effect of Oliceridine(TRV130) on Postoperative Rebound Pain and Early Rehabilitation Exercise After Knee Arthroscopy

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06382896
Enrollment
320
Registered
2024-04-24
Start date
2024-01-01
Completion date
2025-12-31
Last updated
2024-04-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Arthroscopic Knee Surgery, Oliceridine, Rebound Pain

Brief summary

The purpose of this clinical study was to identify the risk factors for postoperative pain outburst in patients undergoing arthroscopic knee surgery after Oliceridine and nerve block, and to evaluate the effect of oxeridine on early rehabilitation exercise in patients. A total of 320 patients undergoing arthroscopic knee arthroscopy under general anesthesia combined with femoral nerve block were selected to record the time and duration of postoperative pain outbreak, pain degree, age, gender, operation type, previous surgical history and other related risk factors.

Interventions

OTHERNo intervention

This was an observational study

Sponsors

The First Affiliated Hospital of Xiamen University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No

Inclusion criteria

1\. Age 18-70 years old;2. Body mass index (BMI) 18-30kg /m2;3. American Society of Anesthesiologists (ASA) Grade I to II;4. Hospital stay \>24h.

Exclusion criteria

1\. Patients who cannot understand the numerical rating scale score and give feedback;2. Known allergy to the drug in the study;3. Infection of puncture site with nerve block;4. Oral analgesics for more than 2 weeks before surgery;5. Long-term use of glucocorticoids;6. Simultaneous surgery on both limbs;7. A psychopath;8. Severe compound trauma;9. Pregnant and lactating women.

Design outcomes

Primary

MeasureTime frameDescription
Time of onset of postoperative rebound painWithin 48 hours after surgeryThe numerical rating scale was used
The duration of the rebound painWithin 48 hours after surgeryThe numerical rating scale was used
The degree of the rebound painWithin 48 hours after surgeryThe numerical rating scale was used
ageWithin 48 hours after surgeryFill in the postoperative questionnaire
sexWithin 48 hours after surgeryFill in the postoperative questionnaire
Surgical procedureWithin 48 hours after surgeryFill in the postoperative questionnaire
Previous surgical historyWithin 48 hours after surgeryFill in the postoperative questionnaire

Secondary

MeasureTime frameDescription
Movement recovery timeWithin 7 days of surgeryFill in the postoperative questionnaire

Countries

China

Contacts

Primary ContactBin Yang, doctor
yangbin4332@outlook.com13859986036

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026