Anesthesia and Analgesia, Anesthesia, Endotracheal
Conditions
Keywords
Opioid free anesthesia, Ocular surgery, Ophthalmology surgery, Dexmedetomidine, Post operative nausea and vomiting
Brief summary
Anesthesia without the use of opioid (Opioid free anesthesia) is an alternative to conventional opioid balanced anesthesia, with less post operative nausea and vomiting, and comparable analgesia. This study aim to compare the effect of opioid free versus opioid balanced anesthesia in ophthalmology surgery
Interventions
DRUGDexmedetomidine
Opioid free anesthesia
DRUGFentanyl
Control given Opioid balanced anesthesia
Sponsors
Indonesia University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Physical status of ASA 1-2 * Undergo elective ophthalmology surgery under general anesthesia with laryngeal mask insertion * BMI 17.5-34.9
Exclusion criteria
* Allergy to study drugs * Baseline heart rate \< 70 beat per minute or systolic blood pressure \< 100 mmHg * Will undergo regional block * Operation lasting for \> 4 hours or \< 90 minutes * Consumes opioid routinely prior to operation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative nausea and vomiting (PONV) | 24 hours | Incidence of PONV |
| Pain score | 24 hours | Pain score assessed with numerical rating scale (0-10) where higher value corresponds to more pain experienced by the patient |
| Time to laryngeal mask exertion | Intraoperative | Measured from the last surgical knot to LMA exertion |
| Adverse effect | 24 hours | Severe changes in hemodynamics, including severe bradycardia, tachycardia, hypotension, hypertension, desaturation |
Outcome results
None listed