End Stage Liver DIsease, Liver Transplantation, Old Age
Conditions
Keywords
liver transplantation, old recipients, age>70 years
Brief summary
Increased life expectancy and aging population has led to a trend of increasing liver transplant (LT) volume in the elderly. Nowadays, advanced age is not considered an absolute contraindication for LT but elderly LT candidates typically have an age-associated burden of comorbid conditions that can pose several clinical challenges during the selection/evaluation process for LT. Specific algorithms for elderly patient selection for LT are not well established; however, consensus agreement is that elderly LT candidates need a more rigorous selection process. This study proposes a step by step algorithm of selection for liver transplant candidates more than 70 years.
Interventions
PROCEDURELiver transplantation
Liver transplantation
Sponsors
Azienda Ospedaliera di Padova
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
71 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Age \>70 years and ≤ 75 years * Liver transplant from cadaveric donor * First liver transplant * End stage liver disease or liver tumor
Exclusion criteria
* Age ≤ 70 years * Living donor liver transplant * Previous liver transplant * Liver transplant for acute liver failure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 1 year patient survival | 12 months | Overall patients survival at 12 months from liver transplantation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 1 year graft survival | 12 months | Overall graft survival at 12 months from liver transplantation |
| 3 months mortality and morbidity | 3 months | Mortality and morbidity rates at 3 months from liver transplantation |
Countries
Italy
Contacts
Primary ContactUmberto Cillo, Prof
Backup ContactAlessandro Vitale, Prof
Outcome results
None listed