Bladder Cancer, Immunotherapy, Radiomics
Conditions
Brief summary
The aim of this study was to develop an radiomic model based on CT images to evaluate markers of the bladder cancer microenvironment, such as TSR,TIL, and IP. Secondly, the association of the radiomic model with clinical outcomes and immunotherapy response was investigated.
Interventions
None listed
Sponsors
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. At least 18 years of age; 2. Performing TURB-t or RC during 2010-2022; 3. The primary lesion was located in the bladder, and the pathological diagnosis was urothelial carcinoma; 4. Complete clinical information, pathological data, preoperative pelvic enhanced CT and follow-up records;
Exclusion criteria
1. Patients with distant metastasis; 2. Combined with other malignant tumors or malignant tumor treatment history 3. Malignant tumors of upper urinary tract; 4. Clinical information, pathological data, preoperative pelvic enhanced CT and follow-up records were missing; 5. Other situations in which the researcher considers it inappropriate to participate in this study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Tumour-infiltrating lymphocytes (TIL) | 1 year | TILs were evaluated using paraffin-embedded tumour tissue samples stained with H&E according to established protocols. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| cancer-specific survival | 1 year | We obtain this data through telephone follow-up and evaluate it according to the date of surgery |
| overall survival | 1 year | We obtain this data through telephone follow-up and evaluate it according to the date of surgery |
Countries
China
Outcome results
None listed