Anorexia Nervosa
Conditions
Brief summary
Aims of this follow-up study are to investigate effects of anorexia nervosa on brain structure and functions in adolescence.
Detailed description
Anorexia nervosa is severe mental health problem with increased incidence rates in adolescence. Etiology of anorexia nervosa is still mostly unkonwn. Adolescence is also critical period of brain development. Aims of this follow-up study are to investigate effects of anorexia nervosa on brain structure and functions in both acute and remission state of anorexia nervosa in adolescence. Study group are young anorexia nervosa patients, and control group are healthy same-aged students. Research methods include non-invasive brain imaging methods such as Transcranial Magnetic Stimulation (TMS), and Magnetic Resonance Imaging (MRI). Other research methods are assessment of body composition, laboratory tests, self-rated questionnaires and psychiatric interview.
Interventions
OTHERObservational study methods
Neuroimaging, body compostion, laboratory tests and psychiatric interview in study and in control groups.
Sponsors
Kuopio University Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
16 Years to 19 Years
Healthy volunteers
Yes
Inclusion criteria
Study group: 1) age 16-19 years, 2) BMI below 17.5, 3) diagnosis: anorexia nervosa or atypical anorexia nervosa 4) diagnosed within last two years. Inclusion criteria. Control group : 1) age 16-19 years, 2) BMI over 19.0, 3) No lifetime obesity (BMI over 30) nor eating disorder.
Exclusion criteria
1\) glucose metabolism disorder or any chronic medical disorder, or medicine with possible effects on neurotransmitters, 2) previous mental health problem (excluded anorexia nervosa or atypical anorexia nervosa in study group), 3) smoking, nicotine products, alcohol or any other substance abuse or dependence, 4) contraindication for used brain imaging method.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Neuroimaging | Baseline and at 3 years' follow-up | Transcranial magnetic stimulation (TMS) combined with electroencephalogram (EEG) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Neuroimaging | Baseline and at 3 years' follow-up | Magnetic resonance imaging (MRI) |
Other
| Measure | Time frame | Description |
|---|---|---|
| Psychiatric evaluation | Baseline and at 3 years' follow-up | Self-rated questionnaires measuring somatic and mentalh health (such as EDE-Q, BDI, substance use measurements) and structured psychiatric diagnostic interview (SCID) |
| Body composition measurement | Baseline and at 3 years' follow-up | InBody body composition measurement (non-invasive method to measure information about the quantity and segmentation of muscle, bone and fat tissue in body and about your basal metabolic rate) |
| Laboratory tests | Baseline and at 3 years' follow-up | Blood sample (markers describing undernourishment, more precise description before study) |
Contacts
Primary ContactVirve Kekkonen, M.D.
Outcome results
None listed