Fungal Infection Lungs
Conditions
Brief summary
Large doses of systemic corticosteroids ，severe lung tissue damage and longer COPD diagnosis may increase the risk of IPA in patients with chronic structural lung disease. By comparing the risk factors of aspergillus colonization group and aspergillus infection group, the main risk factors of aspergillus pneumonia were determined.
Detailed description
Patients with chronic lung disease were identified as positive for Aspergillus fumigatus through sputum microscopy. According to diagnostic criteria, patients diagnosed with IPA and CPA and were assigned to the Aspergillosis pneumonia group, while the remaining patients were included in the Aspergillus colonization group. Then,Risk factors for aspergillus pneumonia, invasive pulmonary aspergillus disease, and chronic pulmonary aspergillus disease, such as the use of high-dose corticosteroids, inhaled corticosteroids, and the extent of damage to basic lung structures, were identified by comparing the aspergillus colonization group with the aspergillus infection group.
Interventions
OTHERNo intervention
No intervention
Sponsors
Lin Chen
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age : at least 18 years old ; 2. Imageological examination : Patients who complete high-resolution computed tomography (HRCT) images of the chest; 3. Serological examination : Patients who complete serological test results, including serum aspergillus specific IgG antibody, serum aspergillus IgM antibody and GM antigen detection.
Exclusion criteria
1. immunodeficiency conditions : Patients diagnosed with HIV infection, hematological malignancies, and autoimmune diseases. 2. Critically ill patients : Those who require mechanical ventilation in the ICU and have established various types of cardiopulmonary bypass. 3. Inadequate Clinical Data: Inability to provide reliable diagnostic measurements or insufficient clinical information.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Descriptive statistical index | Information was collected on the day of admission | Summarize participant characteristics using means and standard deviations for continuous variables and frequencies for categorical variables |
| Independent risk factor for aspergillus pneumonia | Statistical analysis was carried out after data collection within one month | Independent risk factors for aspergillus infection were determined by multivariate logistic regression analysis. |
| The area under ROC curve of risk factors for aspergillus pneumonia | Statistical analysis was carried out after data collection within two month | The area under ROC curve (AUC) was used to evaluate the classification effect of the binary classification model among Aspergillus pneumonia group, IPA group and CPA group |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Threshold analysis of aspergillus pneumonia | Statistical analysis was carried out after data collection within two month | Specific cut-off values for Aspergillus specific IgG antibody × lung structural injury image score was determined to maximize diagnostic accuracy, focusing on sensitivity, specificity, and Youden index. |
Countries
China
Outcome results
None listed