Aphthous Recurrent Ulcers, Oral Ulcer
Conditions
Keywords
photodynamic therapy, aphtous ulcer, indocyanine green
Brief summary
The search for methods that can shorten the treatment process of aphthous ulcers, the etiology of which is not fully understood, continues. The aim of this study was to determine whether photodynamic therapy (PDT) is a clinically effective alternative in the treatment of oral aphthous ulcers.
Detailed description
After sample size calculation, photodynamic therapy and control groups were formed with 15 patients with aphthous ulcer in each group. Laser therapy with indocyanine green was applied to the photodynamic therapy group on the day they were admitted to the clinic. No treatment was performed in the control group and only follow-up was performed. Lesion diameters, pain intensity and degree of improvement at the end of 1 week were recorded in all patients.
Interventions
COMBINATION_PRODUCTPhotodynamic therapy (indocyanine green+laser)
Photodynamic therapy with indocyanine green
Sponsors
Yuzuncu Yil University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* ASA-1 patients without any systemic disease, * With a history of canker sores not exceeding 2 days, * Not taking any antibiotics or anti-inflammatory drugs.
Exclusion criteria
* Laser therapy contraindicated, * Pregnancy, * Smoking habbit, * Poor oral hygiene, * Patients under 18 years of age
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ulcer wound healing with diameter measurement | One week (preoperatively and on postoperative days 3, 5 and 7 ) | Lesion diameters were measured with a elastic ruler and the healing rate of the lesion was monitored. |
| Level of recovery | Postoperatively 7 th day | A 3-point scale was used. Grade 1 represents complete recovery, Grade 2 represents moderate recovery, Grade 3 represents little recovery. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pain evaluation with Visual Analogue Scale | One week | For lesion-related pain follow-up, patients in the PDT group were asked to score the pain they felt on VAS on preoperative, 1st, 3rd, 5th and 7th days. VAS measurements of the patients in the control group were made on days 1, 3, 5 and 7. |
Countries
Turkey (Türkiye)
Outcome results
None listed