Colorectal Cancer
Conditions
Brief summary
The goal of this observational study is to explore the association of peptidoglycan fragments derived from gut microbiota with colorectal cancer (CRC). The main question it aims to answer is: Are peptidoglycan fragments from the gut microbiota associated with the progression of colorectal cancer? Participants will provide biological specimens (blood, feces, colon tissue obtained during surgery)
Detailed description
To explore whether peptidoglycan fragments can be used as screening or diagnostic indicators for colorectal cancer
Interventions
observational study, no intervention
Sponsors
Zhujiang Hospital
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* People who underwent total colonoscopy in gastroenteroscopy room. * People who agree to participate in this study and are willing to sign informed consent.
Exclusion criteria
* Previous diagnosis of malignant tumors other than colorectal cancer. * Received any of the following drug treatments within 1 month before sample collection: ① Drugs used for the treatment of colorectal diseases; ② Antibiotics; ③probiotics; ④ Laxatives. * Patients with a family history of colorectal cancer.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| HPLC-MS/MS was used to detect peptidoglycan fragment content in biological specimens of 200 participants | baseline (before treatment) | The content of peptidoglycan fragments was detected by HPLC-MS/MS |
Countries
China
Contacts
Primary ContactHu Mengyao
Outcome results
None listed