Coronary Artery Calcification, Coronary Artery Disease
Conditions
Keywords
Coronary Disease, Coronary Artery Calcium, Cardiovascular Diseases, 18F-FDG PET/CT (Flourine-18 fluorodeoxyglucose positron emission tomography/computed tomography), Enhanced CT (computed tomography)
Brief summary
Calcification artery calcium (CAC) scoring is a valuable tool for determining the risk of major adverse cardiac events. It was found that CAC can be quantitatively assessed, by manual scoring or using deep-learning, on low-dose non electrocardiogram-gated, contrast-enhanced or non-enhanced computed tomography (CT-scan) performed in association of PET acquisition, with a good agreement with standard scans. The purpose of this study is to determine the impact of a systematic coronary artery calcification evaluation in patients undergoing flourine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) imaging to improve primary prevention of cardiovascular diseases. A visual calcification artery calcium assessment will be made for each patient, dividing them into four groups: none, mild, moderate or heavy calcification artery calcium. When possible, a calcification artery calcium score will be computed. Each patient will complete a questionnaire to collect risk factors, history of cardiovascular diseases and medications.
Interventions
OTHERQuestionnaire
Self-administered questionnaire to assess the participants risk factors, history of heart disease and medications.
Sponsors
Centre Hospitalier Régional d'Orléans
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients referred for a 18F-FDG PT/CT imaging * Patients aged 18 and older
Exclusion criteria
* Patients who already participated in this study (in case of follow-up PET/CT scans) * Unusable CT scan due to CT artifacts or poor-quality images * Patients referred for a brain 18F-FDG PET/CT imaging * Minors, * Protected adults * Pregnant or breastfeeding women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of moderate calcification artery calcium (CAC) in participants without history of cardiac disease | Baseline | In participants who had neither history of cardiac disease nor cardiology follow-up, the proportion of those with at least moderate CAC |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of coronary heart disease among participants | Baseline | Proportion of participants with history of coronary heart disease, according to questionnaire data |
| Correlation of CAC with the medical indication for PET imaging | Baseline | Dividing participants into subgroups according to PET indication, determine in which subgroup the proportion of participants with at least moderate CAC is the highest |
| Prevalence of CAC in young participants (< 45 years old) | Baseline | Proportion of young participants with at least mild CAC |
| Prevalence of moderate CAC in participants not taking low-cholesterol drug | Baseline | In participants not taking low-cholesterol drug, proportion of them with at least moderate CAC |
| Prevalence of no CAC in participants taking statins | Baseline | In participants taking statins, proportion of them without CAC |
Countries
France
Outcome results
None listed