Heart Failure With Preserved Ejection Fraction, Prognathism
Conditions
Keywords
Heart Failure with Preserved Ejection Fraction, Bilirubin, Prognosis
Brief summary
Factors influencing the prognosis of patients with heart failure with preserved ejection fraction (HFpEF) have been extensively studied. Previous studies have found that elevated serum total bilirubin levels are associated with cardiac death, heart failure readmission, and all-cause mortality in patients with chronic heart failure. However, the relationship between direct bilirubin and prognosis in patients with HFpEF is unclear.
Detailed description
Patients with heart failure with preserved ejection fraction account for approximately 50% of all heart failure patients, have approximately 1.4 hospitalisations per year and an annual mortality rate of approximately 15%. Till now, there have no definitively proven therapies that can reduce their morbidity and mortality, HFpEF Patients have a poor prognosis. The current study found that the prognosis of patients with HFpEF may be related to the heterogeneity of the disease, its various phenotypes and multifactorial pathophysiology, which has not been fully elucidated. The current study found that bilirubin is a risk factor for adverse outcomes of various HFpEF-related complications, but the relationship between direct bilirubin and prognosis of HFpEF has not been reported. Therefore the investigators speculate that direct bilirubin is a predictor of prognosis of HFpEF patients.
Interventions
None listed
Sponsors
Chongqing Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult aged ≥18 years old； * Diagnosed with HFpEF. Diagnostic criteria including: 1. left ventricular ejection fraction ≥ 50%; 2. with the symptoms and/or signs of heart failure; 3. Patients in sinus rhythm：BNP≥35pg/ml and/or NT-proBNP≥125pg/ml；Patients with atrial fibrillation：BNP≥105pg/ml and/or NT-proBNP≥365pg/ml.
Exclusion criteria
* LVEF less than 49% at any time
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The level of direct bilirubin | The day when patients on admission | The level of direct bilirubin |
| a composite of heart failure rehospitalization or all-cause mortality | In an average of 3 year after discharge | a composite of heart failure rehospitalization or all-cause mortality |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| heart failure rehospitalization | In an average of 3 year after discharge | heart failure rehospitalization |
| all-cause mortality | In an average of 3 year after discharge | all-cause mortality |
Countries
China
Contacts
Primary ContactDongying Zhang, doctor
Outcome results
None listed