Angiosarcoma
Conditions
Brief summary
This study will be a multi-institutional, prospective, observational study of patients with localized primary AS of any site within ISG and RTR centers. Patients will be treated according to clinical practice of the center and according to ISG clinical recommendations on localized AS.
Detailed description
The management of localized AS remains a clinical challenge and needs to be better defined and standardized, especially with regards to the role of radiation-therapy and systemic treatment. Several questions about the best treatment approach to some clinical presentations remain open and would need to be answered by clinical studies. Unfortunately, the rarity of this histology among sarcomas makes it challenging to carry out clinical studies in all such presentations. Moreover, prognostic factors are lacking and differences in epidemiological, pathological and clinical aspects between primary AS and secondary AS need to be better characterized. These issues may be addressed with a prospective multi-institutional observational study, through the collection of clinical and pathological data of patients with localized AS. Involving all reference centres for sarcoma in Italy, the Italian Sarcoma Group (ISG) will be the ideal network for this study, with the collaboration of the Italian Rare Cancer Network (RTR), a 7collaborative network among Italian centres focusing on improving the quality of care of patients with rare tumors.
Interventions
OTHERObservational
Observational
Sponsors
Italian Sarcoma Group
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* pathological diagnosis of AS; * any site of origin; * any age; * primary, localized, resectable disease.
Exclusion criteria
NA
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Demographic characteristics | At the time of enrollment | Demographic data |
| General characteristics | At the time of enrollment | Comorbidities |
| Cancer data | At the time of enrollment | Previous cancer data |
| Origin of Tumor | At the time of enrollment | Site of origin |
| Tumor characteristics | At the time of enrollment | Multifocality |
| Tumor size | At the time of enrollment | Size |
| Tumor aspects | 10 years | Morphological aspects |
| Pathological characteristics | 10 years | Proliferative index |
| Tumor phenotype | 10 years | Tumor cell phenotype |
| Molecular characteristics | 10 years | Molecular aspects |
Countries
Italy
Contacts
Primary ContactGianluca Ignazzi
Backup ContactViviana Appolloni
Outcome results
None listed