Post Operative Pain
Conditions
Brief summary
Many patients undergoing laparoscopic cholecystectomy are prone to developing acute and chronic post-operative pain. The aim of the study is to show a possible correlation between pain and acute phase proteins in order to: * predict the severity of pain; * select most suitable pain relief therapy for the patient.
Detailed description
The day after surgery, some serum markers are determined by a blood sample. The markers analyzed are: * Leukocytes; * C-reactive protein (CRP); * D-dimer; * Fibrinogen; * Neutrophil-to-Lymphocyte Ratio (NLR). Pain level is assessed using the NRS scale at different times: * 1st post-operative day; * 7th post-operative day; * One month after surgery; * Three months after surgery; * Six months after surgery. Other data collected for the study are: gender, age, BMI.
Interventions
PROCEDURElaparoscopic cholecystectomy
A blood sample is taken the day after surgery
Sponsors
University of Roma La Sapienza
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patient undergoing laparoscopic cholecystectomy
Exclusion criteria
* children
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Relationship Between Post-operative Pain and C Reactive Protein (CRP) in Laparoscopic Cholecystectomy | one day | The study compares post-operative pain, measured with the NRS scale, with CRP (µg/L) levels 24 hours after surgery |
| Relationship Between Post-operative Pain and D-dimer in Laparoscopic Cholecystectomy | one day | The study compares post-operative pain, measured with the NRS scale, with D-dimer (µg/L FEU) levels 24 hours after surgery |
| Relationship Between Post-operative Pain and Fibrinogen in Laparoscopic Cholecystectomy | one day | The study compares post-operative pain, measured with the NRS scale, with fibrinogen (g/L) levels 24 hours after surgery |
| Relationship Between Post-operative Pain and white blood cell count in Laparoscopic Cholecystectomy | one day | The study compares post-operative pain, measured with the NRS scale, with white blood cell count (x 10\^9/L) 24 hours after surgery |
| Relationship Between Post-operative Pain and Neutrophil to Lymphocyte Ratio (NLR) in Laparoscopic Cholecystectomy | one day | The study compares post-operative pain, measured with the NRS scale, with Neutrophil to Lymphocyte Ratio (NLR) 24 hours after surgery. NLR results from the ratio between the level of neutrophils and lymphocytes. |
Countries
Italy
Contacts
Primary ContactAugusto Lauro
Backup ContactLauro
Outcome results
None listed