Investigating the Plasticity of Human Predictive Coding Through Neuromodulation

Investigating the Plasticity of Human Predictive Coding Through Neuromodulation: an Interventional, Monocentric, Randomized, Single-blinded Study on Healthy Adult Volunteers

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06374433

Acronym

PREDICOM

Enrollment

210

Registered

2024-04-18

Start date

2024-06-13

Completion date

2026-12-31

Last updated

2024-06-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Human Brain and Cognition

Brief summary

The hypothesis of the study is to investigate how different trm (tES) methods (transcranial Alternating Current Stimulation, tACS, and transcranial Random Noise Stimulation, tRNS) applied at different stimulation frequencies and networks can modulate the predictive mechanisms in human perception and cognition. This is an interventional, monocentric, cross-sectional randomized, single-blinded study on healthy adult volunteers, recruited through online advertisements, flyers and oral transmission. Volunteers will be recruited from the general population of young adults.

Interventions

PROCEDUREOccipital tACS at IAF-2Hz

tACS applied to occipital areas at 2 Hz below the individual alpha frequency (IAF)

PROCEDUREOccipital tACS at IAF+2Hz

tACS applied to occipital areas at 2 Hz above the individual alpha frequency (IAF)

PROCEDUREFrontal tACS at 4-7 Hz

tACS applied to frontal areas at 4-7 Hz

PROCEDUREOccipital tRNS

tRNS applied to occipital brain regions

PROCEDUREFrontal tRNS

tRNS applied to frontal brain regions

PROCEDURESham/placebo tACS

tACS is activated only for 30 seconds and then turned off, thus resulting ineffective

PROCEDURESham/placebo tRNS

tRNS is activated only for 30 seconds and then turned off, thus resulting ineffective

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* Participant is willing and able to give informed consent for participation in the study. * Aged 18-35 years. * Normal or corrected to normal vision, as per anamnestic investigation.

Exclusion criteria

* Participants with a diagnosis of epilepsy (as per anamnestic investigation). * Participants with major neurological disorders (as per anamnestic investigation). * Participants that are currently under psychopharmacological treatment with tricyclic antidepressants (as per anamnestic investigation). * Participants with metal implants in the brain, pacemakers, brain stimulators, cochlear implants (as per anamnestic investigation).

Design outcomes

Primary

Measure	Time frame	Description
Behavioral measures	During the procedure	To study if tACS or tRNS delivered in different brain networks can modulate the learning of statistical regularities in the context of visual perception we will evaluate the following behavioral measures recorded in a computerized visual perception task: hit rate, miss, false alarms, correct rejections. These behavioral measures will allow to derive measures of sensitivity (d') and response criterion (Beta and C), according to the theoretical framework of the Signal Detection Theory (SDT).

Countries

Italy

Contacts

Primary ContactLuca Ronconi, PhD

ronconi.luca@unisr.it0226434887

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026