Longevity Families of the Netherlands

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06374069

Acronym

LOF-NL

Enrollment

600

Registered

2024-04-18

Start date

2023-09-11

Completion date

2026-12-01

Last updated

2026-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aging, Extreme Longevity, Familial Longevity, Longevity

Brief summary

The demographic life expectancy enhancement of the past 150 years imposes an urgent challenge in Western and economically growing societies to stimulate the healthy lifespan that is lagging behind. Families surviving into exceptionally high ages (longevity) in good physical and mental health illustrate that this is physiologically possible. Such families harbor cross generational socio-genetic mechanisms that mediate healthy aging and protection from (multi)morbidity. The purpose of our research is: to identify gene variants associated with healthy aging and protection from (multi)morbidity; to study the social-, environment- and behavioral factors of familial longevity, their role in (multi-)morbidity and its interaction with the genetic component.

Interventions

None listed

Study design

Observational model

FAMILY_BASED

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

75 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Siblings of Dutch Caucasian descent age 75+ enriched for familial longevity * Individuals of Dutch Caucasian descent age 75+ who are not enriched for familial longevity

Exclusion criteria

Design outcomes

Primary

Measure	Time frame	Description
Identifying the genetic variants of Familial Longevity	through study completion, an average of 2 years	To identify gene variants associated with healthy aging and protection from (multi)morbidity

Secondary

Measure	Time frame	Description
Studying the environmental factor of Familial Longevity through questionnaires and its interaction with the genetic component	through study completion, an average of 2 years	To study the social-, environment- and behavioral factors of familial longevity, their role in (multi-)morbidity and its interaction with the genetic component

Countries

Netherlands

Outcome results