Adverse Events for Free Flap Surgery in Head and Neck Cancer

Prescription Pattern and Adverse Events of Postoperative Antithrombotic Regimes for Free Flap Surgery in Head and Neck Cancer

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06371365

Enrollment

540

Registered

2024-04-17

Start date

2022-10-19

Completion date

2023-09-24

Last updated

2024-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Flap Failure Risk Factors, Hematoma Risk Factors, Surgical Flaps, Thrombosis Risk Factors

Brief summary

This is a cohort study collecting patients with head and neck cancer who underwent free flap surgery at a single medical center between January 2019 and January 2022.

Detailed description

Patient information are collected from the electronic medical records retrospectively: Head and Neck cancer diagnosis: The International Classification of Diseases, Tenth Revision (ICD-10), which included C00-C14, C31, C32, C73, C75.0, C75.4 and C41.1. The cancer stage, alcohol use, betel nut, and smoking, and baseline comorbidities. Surgical characteristics including flap history, ablation time, reconstruction time, donor sites, recipient sites, neck dissection, flap size, anastomosis, artery types, vein types, intraoperative sealants used, and intravenous calcium channel blocker nicardipine to control hypertension after surgery.

Interventions

PROCEDUREFree Flap surgery

No intervention, this is an observational study

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age greater and equal to 20 years old * Underwent free flap surgery * Had head and neck cancer

Exclusion criteria

* HIV positive * Pregnant, breast feeing women * Missing surgical charts

Design outcomes

Primary

Measure	Time frame	Description
Number of participants with flap failure	30 days post-operation	Flap necrosis with a need for a new flap or other surgical procedures.

Secondary

Measure	Time frame	Description
Number of participants with hematoma	30 days post-operation	Surgical indication for reoperation. Reoperation is performed when patients experienced major complications refractory to bedside management.
Number of participants with thrombosis	30 days post-operation	Surgical indication for reoperation. Reoperation is performed when patients experienced major complications refractory to bedside management.

Countries

Taiwan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026