Attention, EEG With Periodic Abnormalities, Fluency Disorder, Social Behavior, Visual Perceptual Weakness
Conditions
Brief summary
Results of the application of 100 sessions of tDCS for 12 months in children between 6 and 11 years old with autism spectrum disorder with rare diseases, genetic problems or PANDAS
Detailed description
tDCS will be applied to 90 children diagnosed with ASD with Mu activity in one of their two temporal lobes and to another 90 children tDCS will not be applied but rather conventional treatments such as the Denver method, etc., in addition to collecting their electroencephalograms in eyes open condition, evoked potentials will be performed. with Mismatch Negativity paradigm to calculate the P300 wave every 25 sessions with a rest of 5-6 weeks between every 25 sessions and the changes in voltage and frequency of the EEG will be analysed using FFT & PSD, as well as the latencies and amplitudes of its P300 wave.
Interventions
DEVICEtDCS or Transcranial Direct Current Stimulation
We use weak currents applied over the child's scalp over 30 minutes twice a week during 100 days
DRUGRisperidone
Risperidone Risperidone according to child's weighs
OTHERSham tDCS
Participants will receive sham transcranial direct current stimulation (tDCS). The device and electrode placement will be identical to the active stimulation groups, but the electrical current will be turned off after a brief initial ramp-up period to mimic the physical sensation of active tDCS without delivering therapeutic stimulation.
Sponsors
Spanish Foundation for Neurometrics Development
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Masking description
Assessments regarding clinical recovery will be conducted by an assessor blind to treatment allocation.
Intervention model description
Two groups of childs: 90 childs receive tDCS treatment and 90 traditional treatments with Risperidone educational training, speech therapy and visual training.
Eligibility
Sex/Gender
ALL
Age
6 Years to 11 Years
Healthy volunteers
No
Inclusion criteria
* Age between 7 and 15 years old * Diagnosis: PDD, ASD or PANDAS * Have genetic alterations with geneticist reports like: mutation, random mating between organisms, random fertilization or crossing over (or recombination) between chromatids of homologous chromosomes during meiosis. * Natural birth without caesarean or complications * Normal Pregnancy
Exclusion criteria
* Head Trauma * Brain Injuries like meningitis or encephalitis, including SaRS, Herpes or MERS infections * Epilepsy * Rare Diseases with Auto-Immune Disease * Rare diseases with Endocrinology problems * Fever or Biochemical problems in the First Blood Test (First Visit) * Vaccines Reactions
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| FFT | 12 months | Change in Voltage for every frequency band |
| Power Density Spectrum Changes or PSD | 12 Months | Amplitude of the PSD |
| ERP MMN changes | 12 months | Changes in P300 wave amplitude |
| ERP MMN Changes | 12 Monts | Changes in P300 wave latency |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Attention | 12 months | Using ATTC scale average Scale |
| Social Skills | 12 months | We used SSRS Scale Total Teacher Scale |
| Language | 12 months | GhostBusters Res Spoken Language and Listening Average Score from 40 Cards |
| Visual Contact | 12 months | P200 wave amplitude in occipital lobe |
Countries
United States
Outcome results
None listed