Healthy Nutrition, Diet, Healthy
Conditions
Keywords
medium-chain fatty acids, lipidomics, acute intervention
Brief summary
In the present study the plasma lipid profile was elucidated in healthy, lean males by the use of lipidomic analysis in the hours after an acute intake of medium-chain fatty acids (MCT) and long chain fatty acids (LCT),, respectively. In addition oxygen uptake was measured to study energy turnover.
Detailed description
Four participants ingested MCT or LCT oil on two test days with one-week period between the experimental days. The day prior to the experimental days, the participants consumed a eucaloric control diet, and abstained from alcohol and vigorous physical activity to ensure similar conditions on experimental days. On the test days, participants arrived by passive transport in the overnight fasted state (12 h) at 8 a.m., and a catheter was inserted into an antecubital vein. Following 30 min in supine rest, an overnight-fasted, basal venous blood sample was obtained. Subsequently, participants ingested the same test drink as in study 1 (containing 35g of MCT or LCT oil diluted in 100g of low-fat, low-carbohydrate cocoa milk) within five min. 100 ml water was provided together with the test drink. Venous blood samples were drawn every 30 min for the first two hours and every 60 minutes for the last two hours following intake. Participants rested in a bed throughout the test day. this This process was repeated on the second test day.
Interventions
DIETARY_SUPPLEMENTLipidomics
Health beneficial effects of medium-chain fatty acids
Sponsors
University of Copenhagen
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
This study is a randomized, double-blinded crossover design. Participants ingest Medium-chain-fatty acids (MCT) or Long-chain fatty acids (LCT) oil on two test days with one-week period between the experimental days. The day prior to the experimental days, the participants consume a eucaloric control diet, and abstain from alcohol and vigorous physical activity to ensure similar conditions on experimental days.
Eligibility
Sex/Gender
MALE
Age
20 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
healthy males BMI:20-27 recreationally physical active non-smoker no medicine \-
Exclusion criteria
* high habitual intake of MCT-rich foods as coconut, coconut oil and dairy products
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Meal test including medium-chain fatty acids | 0-4 hours | In this study the effect of an acute intake of MCT oil compared with the intake of LCT (containing 35g of MCT or LCT oil diluted in 100g of low-fat, low-carb cocoa milk ) on the plasma lipid profile is studied in healthy men. Blood is obtained postprandially ( frequently during 4 hours) and analyzed for the plasma lipid profile |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Resting metabolic rate | 0-4 hours | The secondary outcome of this study is to investigate the effect of an acute intake of MCT or LCT oil (35g of MCT or LCT) on resting metabolic rate in healthy lean men |
Countries
Denmark
Outcome results
None listed