Optic Nerve Sheath Diameter: A Non-Invasive Indicator of Intracranial Pressure in the Intensive Care Unit Monitoring

Evaluation of the Effect of Cerebrospinal Fluid Drainage on Optic Nerve Sheath Diameter in Patients Installed External Ventricular Drainage Catheter Due to Intracranial Pathology in the Intensive Care Unit

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06367868

Enrollment

Registered

2024-04-16

Start date

2021-09-09

Completion date

2022-12-01

Last updated

2024-04-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ICP (Intracranial Pressure) Increase, Intracranial Hypertension, Optic Nerve Sheath Diameter

Keywords

ONSD, ultrasonography, noninvasive, increased intracranial pressure

Brief summary

Determination of high intracranial pressure (ICP) is necessary for the treatment of patients with raised ICP to improve long-term neurological outcomes. Ultrasonographic optic nerve sheath diameter (ONSD) measurement is a noninvasive, easily performed and cost effective technique for detecting high ICP.

Detailed description

ICP measurements via ventricular catheters provide CSF drainage and ICP reduction. The normal ICP value is less than 15 mmHg in adults. In the literature the correlation of ONSD and invasive ICP measurements were determined. The aim of study is to evaluate the correlation of ONSD and direct ICP measurements and to determine cut off ONSD value to detect ICP ≥15 mmHg.

Interventions

PROCEDUREAfter 5 ml CSF Drainage

Optic Nerve Sheath Diameter and Intracranial Pressure measurements will be after 5 ml CSF drainage

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* 18-80 aged patients * With an external ventricular drainage catheter due to intracranial pathology

Exclusion criteria

* Under the age of 18 * Orbital tumors * Graves' disease * Exophthalmos * Sarcoidosis * Optic neuropathy * Meningitis * Ocular trauma * Lung diseases

Design outcomes

Primary

Measure	Time frame	Description
Intracranial Pressure-1 (ICP-1)	baseline time	Measurement of intracranial pressure before cerebrospinal fluid (CSF) drainage
Optic Nerve Sheath Diameter-1 (ONSD-1)	baseline time	Measurement of optic nerve sheath diameter before cerebrospinal fluid drainage

Secondary

Measure	Time frame	Description
Intracranial Pressure-2 (ICP-2)	2 minutes after CSF drainage	Measurement of intracranial pressure 2 minutes after cerebrospinal fluid (CSF) drainage
Optic Nerve Sheath Diameter-2 (ONSD-2)	2 minutes after CSF drainage	Measurement of optic nerve sheath diameter 2 minutes after cerebrospinal fluid drainage

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026