Diabetes Mellitus, Type 2, Glucose Intolerance, Insulin Resistance, Insulin Sensitivity, Overweight or Obesity, Sleep Disturbance
Conditions
Keywords
Resistance Exercise, Strength-training, Sleep, Circadian Rhythm
Brief summary
The primary aim of this study is to evaluate if a single bout of AM vs PM resistance exercise has different effects on insulin sensitivity and sleep. A randomized cross-over trial be used to compare resistance exercise at two different times of the day. Each condition will take place in a laboratory setting. Each condition will consist of exercise, overnight sleep, and oral glucose tolerance tests the following day. The AM exercise will occur \ 1.5 hours after habitual wake, and PM exercise will occur \ 11 hours after habitual wake. After a 2-6 week washout, participants will complete the other condition. The hypothesis is that PM exercise will be more beneficial than AM exercise in improving insulin sensitivity. This study could identify if there is a better time of day to perform resistance exercise to decrease risk of developing Type 2 Diabetes Mellitus.
Interventions
BEHAVIORALResistance Exercise Timing
1 resistance exercise session consisting of 3 sets, 10 repetitions per set, on 12 different exercises
Sponsors
University of Utah
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
50 Years to 74 Years
Healthy volunteers
No
Inclusion criteria
* Men and women, all ethnicities, aged 50-74 years * BMI ≥25 kg/m² and \<45 kg/m² * Weight stable (less than 5% change in the past 6 months) * Generally healthy individuals * Not meeting recommended activity guidelines for aerobic or resistance exercise
Exclusion criteria
* Uncontrolled cardiovascular, metabolic, renal, or pulmonary disease * Cancer treatment in the past 5 years * Untreated thyroid disease or other medical conditions affecting weight or energy metabolism * Current use of weight loss medication or other medications likely to impact energy balance * Bariatric surgery or extensive bowel resection in the past 2 years * Current or recent history (past 2 years) of eating disorder * Diagnosis of insomnia, sleep apnea, or other sleep and circadian disorders * Non-English speaking * HbA1c \>6.5%
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Insulin sensitivity | 1 day | Insulin sensitivity will be calculated using the Matsuda Insulin Sensitivity Index |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Sleep Duration | 1 day | Sum of time spent in stage 1, stage 2, stage 3 and rapid eye movement stage (REM) as assessed via polysomnography. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Sleep Efficiency | 1 day | Ratio of time in bed vs time asleep |
| Muscular Strength | 1 day | Muscular strength as assessed via 10 repetition maximum test |
| Perceived Hunger | 1 day | Visual Analog Scales (scale: 0-100) |
| Sleep Staging | 1 day | Time spent in stage 1, stage 2, stage 3 and REM sleep assessed by polysomnography. |
| Perceived Prospective Food Consumption | 1 day | Visual Analog Scales (scale: 0-100) |
| Glucose Area Under Curve | 1 day | Mathematical calculation using fasting, 10,20,30,60,90,120 min blood glucose |
| Insulin Area Under Curve | 1 day | Mathematical calculation using fasting, 10,20,30,60,90,120 min blood insulin |
| Perceived Fullness | 1 day | Visual Analog Scales (scale: 0-100) |
| Sleep Quality | 1 day | As assessed via Pittsburg Sleep Quality Index Questionnaire (scale:0-21, higher scores=worse outcome) and polysomnography |
Countries
United States
Contacts
Primary ContactTanya M Halliday, PhD
Backup ContactStudy Email Study Email
Outcome results
None listed