Pulmonary Hypertension
Conditions
Brief summary
The aim of the study is to observe the change of the circulating MrgD level in patients with pulmonary hypertension compared with subjects without pulmonary hypertension.
Interventions
DIAGNOSTIC_TESTWestern blot
Samples were measured by Western blot using a solution for the separation of lymphocytes from peripheral blood.
Sponsors
Qilu Hospital of Shandong University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
for patients with pulmonary hypertension： 1. Male or female aged ≥18 years 2. Right heart catheterisation to check the mean pulmonary artery pressure (mPAP) ≥25mmHg 3. The patient is willing and able to provide written informed consent.
Exclusion criteria
for patients with pulmonary hypertension： 1. Age less than 18 years old 2. Mean pulmonary artery pressure (mPAP) \<25mmHg 3. Unable to provide informed written consent for participation in the study 4. Renal insufficiency 5. Liver insufficiency 6. Malignant tumor 7. Active infection 8. Pregnancy Inclusion criteria for control subjects： 1. Male or female aged ≥18 years 2. No evidence of pulmonary hypertension on echocardiography or mean pulmonary artery pressure (mPAP) \< 25 mmHg on right heart catheterization, and no evidence of clinically relevant heart disease 3. No evidence of clinically relevant pulmonary disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Circulating MrgD level | From 2022 to 2024 |
Countries
China
Contacts
Primary ContactPanpan Hao, MD
Outcome results
None listed