Post Operative Hemorrhage
Conditions
Keywords
Direct Oral Anticoagulants, oral Surgical Procedure, Post-operative complications
Brief summary
Evaluation of DOACs treatment on post-extraction bleeding
Detailed description
Consecutive patients requiring at least one dental extraction were enrolled. DOACs regimen was either maintained or suspended. Patients were classified in subgroups depending on the number of teeth extracted per procedure (≤ 3 or \> 3), the need for flap raising and the performance of osteotomy. Bleeding was recorded intraoperatively, perioperatively at 20, 40, 60 and 80 minutes after the procedure, and in the first seven days post-operatively.
Interventions
None listed
Sponsors
University of Pisa
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age \>18 years * patients under pharmacological treatment with DOACs * patients requiring at least one dental extraction * patients willing to take part in the study and to sign informed consent
Exclusion criteria
* patients below 18 years of age * patients treated with antiplatelet therapy or vitamin K antagonists * patients presenting with an International Normalized Ratio (INR) \>3.0 * patients suffering from congenital or acquired coagulopathies (e.g. haemophilia, coagulation factors deficiency, von Willebrand disease, thrombocytopenia, cirrhosis)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Peri-operative hemorrhage | 20 minutes to 80 minutes | Evaluation of early post-operative hemorrhage classified as absent, mild, oozing, moderate, and severe. |
| Post-operative bleeding | day 1 to 7 post-operatively | Evaluation of post-operative bleeding classified as absent, mild, oozing, moderate, and severe. |
Countries
Italy
Outcome results
None listed