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Comparative Study of Through Knee Amputation Versus Above Knee Amputation Regarding Infection Rate and Function

Comparative Study of Through Knee Amputation Versus Above Knee Amputation Regarding Infection Rate and Function

Status
Not yet recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06365203
Enrollment
60
Registered
2024-04-15
Start date
2024-04-30
Completion date
2026-04-30
Last updated
2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Amputation of Knee

Brief summary

The aim of this study is to search and compare outcomes of through knee amputation (TKA) and above knee amputation (AKA) in terms of Technique ,wound healing ,infection rate , function and ambulation

Detailed description

Severe peripheral arterial disease with or without comorbid diabetes mellitus accounts for the majority of patients requiring major lower extremity amputations. There is also an association between major extremity amputation and lower socio-economic status, attributed to lifestyle and comorbidities, living and working conditions, psychosocial factors, and access to affordable healthcare. With a transfemoral prosthesis, the amputee weight bears through their ischial tuberosity which can cause discomfort when standing or ambulating. These challenges have been associated with greater abandonment of prosthesis use. An often over looked alternative within amputation surgery is through knee amputation (TKA), which currently comprises less than 5% of all major lower extremity amputations. Compared with AKA, TKA is a less traumatic procedure with little disruption to thigh muscles, articular cartilage, menisci, and bone (especially with Knee Disarticulation), which in turn reduces post-operative infection and formation of bone spurs. In contrast, AKA can also provide additional problems. Due to a shorter lever length of the residuum, the unilateral transfemoral amputee requires three times more energy to ambulate with a prosthetic limb compared with a unilateral transtibial amputee. Among vascular surgeons, TKA is similarly rarely performed. Fear of poor wound healing and potential stump breakdown in longer soft tissue flaps needed to cover epicondyles of the distal femur are possible preconceived misconceptions. Historically, outcomes after TKA are acceptable, but scarce vascular literature exists reporting contemporary outcomes of TKA.

Interventions

PROCEDUREThrough knee amputation

Amputation Technique

PROCEDUREAbove knee Amputation

Amputation Technique

Sponsors

Assiut University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

* Critical limb ischemia with sever infection with no role For BKA * Acute late or total ischemia SFA with poor * popliteal signals and no distal run off * Infected Diabetic foot (DF) affecting heel and calf muscle with preserved knee joint * Traumatic gangrene

Exclusion criteria

* Venous gangrene

Design outcomes

Primary

MeasureTime frameDescription
Wound healing rateOne yearRates of healing of different amputees
Incidence of infectionOne year

Secondary

MeasureTime frameDescription
Function of the limb Rehabilitation Quality of lifeTwo yearsIncidence of recurrence
Mortality rateTow years

Contacts

Primary ContactAhmed Mo Adly, Resident
aadly1098@gmail.com+201553287304
Backup ContactAhmed Mu Nagy, Lecturer
ah.mostafa.nagy@gmail.com01009887422

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026