Anthrax
Conditions
Brief summary
This study is a clinical, multi-center, retrospective, case-control study. Patients clinically diagnosed with severe anthrax who meet the inclusion and exclusion criteria will be included in this study for analysis. Respiratory, circulation, nerve and other vital signs of patients with severe anthrax during hospitalization were recorded, and clinical data such as blood routine, blood biochemistry, coagulation function, myocardial injury, therapeutic drug use, and survival time of patients were recorded, as well as the survival situation of patients 28 days and 90 days after discharge.
Interventions
None listed
Sponsors
Qin Ning
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. The typical bacilli with capsules were found in smear examination and culture of various secretions, excretions, blood and cerebrospinal fluid. 2. Multiple organ dysfunction (MODS) in brain, heart, liver, kidney, coagulation or more than one organ failure.
Exclusion criteria
There are other conditions that affect short-term survival.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| mortality rates of severe anthrax | 28 days and 90 days | mortality rates of severe anthrax |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| incidence of complications | in hospital | To evaluate the incidence of respiratory, circulatory, neurological, digestive, coagulation and other complications of severe anthrax |
| Peripheral blood biomarkers associated with 28-day and 90-day mortality | 28 days and 90 days | Peripheral blood biomarkers associated with 28-day and 90-day mortality |
| the improvement in 28-day and 90-day mortality with treatment for severe anthrax | 28 days and 90 days | the improvement in 28-day and 90-day mortality with treatment for severe anthrax |
Countries
China
Contacts
Primary ContactQin Ning, professor
Outcome results
None listed